SC 66
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- CAS号:
- 871361-88-5
- 英文名:
- SC 66
- 英文别名:
- SC 66;CS-2480;SC66;SC 66;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
- 中文名:
- SC 66
- 中文别名:
- 化合物SC66;AKT抑制剂(SC66);(2E,6E)-2,6-二(4-吡啶基亚甲基)环己酮
- CBNumber:
- CB42565930
- 分子式:
- C18H16N2O
- 分子量:
- 276.33
- MOL File:
- 871361-88-5.mol
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SC 66化学性质
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: ≥5mg/mL (warmed)
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形态:
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powder
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颜色:
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faint yellow to dark yellow
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SC 66性质、用途与生产工艺
SC66 是一种 Akt 抑制剂，降低细胞活力，这种作用存在剂量和时间依赖性，且抑制肝癌 (HCC) 细胞的集落形成和诱导凋亡。
SC66 inhibits cell viability and colony forming capacity of HCC cells with IC
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s of 0.77，0.47，0.92，0.75 and 2.85 μg/mL at 72 hours for HepG2, Hep3B, PLC/PRF/5，HA22T/VGH and Huh7 cells. HepG2, HA22T/VGH and PLC/PRF/5 cells have similar IC
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s of approximately 0.85 and 0.75 μg/mL at 48 and 72 hours, respectively. To determine whether the decrease in cell viability is related to apoptosis induction, TUNEL assays are performed in Hep3B and Huh7 cells treated with 1, 2 and 4 μg/mL of SC66 for 24 hours. In Hep3B cells the number of TUNEL-positive cells increased with increasing concentrations of SC66, whereas in Huh7 cells very few light brown-colored cells are observed only after treatment with 4 μg/mL SC66.
To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm
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, mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group.
SC 66
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-19832 | SC 66
SC66 | 871361-88-5 | 5mg | 550元 |
| 2024/01/25 | HY-19832 | SC 66
SC66 | 871361-88-5 | 10mM * 1mLin DMSO | 605元 |
871361-88-5, SC 66 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 化合物SC66
- AKT抑制剂(SC66)
- (2E,6E)-2,6-二(4-吡啶基亚甲基)环己酮
- 871361-88-5
- Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
- (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone
- SC66;SC 66
- CS-2480
- (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
- Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-
- SC 66