174402-32-5
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- CAS号:
- 174402-32-5
- 英文名:
- Edotecarin
- 英文别名:
- J 107088;PF 804950;Edotecarin;Edotecarin (J 107088);5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12-β-D-glucopyranosyl-12,13-dihydro-2,10-dihydroxy-6-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-
- 中文名:
- 174402-32-5
- 中文别名:
- 化合物 T15200
- CBNumber:
- CB42583033
- 分子式:
- C29H28N4O11
- 分子量:
- 608.56
- MOL File:
- 174402-32-5.mol
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174402-32-5化学性质
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熔点:
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330° (dec)
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比旋光度:
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D23 +117° (c = 0.8 in 1:1 acetonitrile/water)
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沸点:
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1047.5±75.0 °C(Predicted)
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密度:
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1.96±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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9.61±0.20(Predicted)
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174402-32-5性质、用途与生产工艺
Edotecarin 是一种有效的 topoisomerase I 抑制剂，可诱导单链 DNA 断裂，IC50 值为 50 nM。
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Topoisomerase I
50 nM (IC
50
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Protein Kinase C
160 μM (IC
50
)
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In the presence of human colon cancer cells labeled with
3
Hthymidine, edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner.
Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect. Edotecarin results in tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Combination treatment of edotecarin plus irinotecan improves antitumor activity in vivo compared with either agent alone.
174402-32-5
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174402-32-5, 174402-32-5 相关搜索:
- C29H28N4O11
- 化合物 T15200
- 174402-32-5
- 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12-β-D-glucopyranosyl-12,13-dihydro-2,10-dihydroxy-6-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-
- Edotecarin (J 107088)
- PF 804950
- J 107088
- Edotecarin