MI-3 (Menin-MLL Inhibitor)
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- CAS号:
- 1271738-59-0
- 英文名:
- MI-3 (Menin-MLL Inhibitor)
- 英文别名:
- MI-3;CS-1809;5-dihydro-5;Menin-MLL inhibitor 3;MI-3 (Menin-MLL Inhibitor);MI-3 (Menin-MLL Inhibitor) USP/EP/BP;5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl);MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine;Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-
- 中文名:
- MI-3 (Menin-MLL Inhibitor)
- 中文别名:
- 化合物MI-3;MI-3,MENIN-MLL 相互作用抑制剂;MI-3(MENIN-MLL INHIBITOR 3);4-[4-(4,5-二氢-5,5-二甲基-2-噻唑基)-1-哌嗪基]-6-异丙基噻吩并[2,3-D]嘧啶
- CBNumber:
- CB42624233
- 分子式:
- C18H25N5S2
- 分子量:
- 375.55
- MOL File:
- 1271738-59-0.mol
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MI-3 (Menin-MLL Inhibitor)化学性质
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沸点:
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527.9±60.0 °C(Predicted)
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密度:
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1.36±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic)
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形态:
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Powder
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酸度系数(pKa):
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9.59±0.40(Predicted)
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MI-3 (Menin-MLL Inhibitor)性质、用途与生产工艺
MI-3 (Menin-MLL抑制剂)可抑制白血病中MLL融合蛋白的致癌活性。
MI-3 (Menin-MLL Inhibitor)是一种强效的menin-MLL相互作用抑制剂,IC50为 648 nM。
在HEK293细胞中,MI-3接近蛋白质靶点,并有效抑制menin-MLL-AF9相互作用。MI-3通过下调MLL融合蛋白致癌活性所需的靶点基因的表达,有效阻断MLL融合蛋白介导的白血病转化。在携带不同MLL易位的人MLL白血病细胞系,MI-3有效阻断细胞分化,并诱导细胞凋亡。
IC50: 648 nM (menin-MLL); Kd: 201 nM (menin-MLL)
MI-3 (Menin-MLL Inhibitor)
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-15223 | MI-3 | | 1 mg | 636元 |
2024/01/25 | HY-15223 | MI-3 (Menin-MLL Inhibitor) MI-3 | 1271738-59-0 | 5mg | 1400元 |
MI-3 (Menin-MLL Inhibitor)
生产厂家
1271738-59-0, MI-3 (Menin-MLL Inhibitor) 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 活性小分子库
- 小分子抑制剂,天然产物
- 小分子抑制剂
- MI-3,MENIN-MLL 相互作用抑制剂
- 化合物MI-3
- MI-3(MENIN-MLL INHIBITOR 3)
- 4-[4-(4,5-二氢-5,5-二甲基-2-噻唑基)-1-哌嗪基]-6-异丙基噻吩并[2,3-D]嘧啶
- 1271738-59-0
- MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor
- MI-3 (Menin-MLL Inhibitor) USP/EP/BP
- CS-1809
- MI3;MI 3;MENIN-MLL INHIBITOR 3;THIENO[2;3-D]PYRIMIDINE; 4-[4-(4;5-DIHYDRO-5;5-DIMETHYL-2-THIAZOLYL)-1-PIPERAZINYL]-6-(1-METHYLETHYL)
- 5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)
- 5-dihydro-5
- 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3
- MI-3 (Menin-MLL Inhibitor)
- 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine
- Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-
- Menin-MLL inhibitor 3
- MI-3