DUOCARMYCIN
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- CAS号:
- 1116745-06-2
- 英文名:
- DuocarMycin
- 英文别名:
- DuocarMycin;Duocarmycin DM free base;Methanone, [(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl][5-[2-(dimethylamino)ethoxy]-1H-indol-2-yl]-
- 中文名:
- DUOCARMYCIN
- 中文别名:
- 化合物 T11119
- CBNumber:
- CB42686725
- 分子式:
- C26H26ClN3O3
- 分子量:
- 463.96
- MOL File:
- 1116745-06-2.mol
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DUOCARMYCIN化学性质
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沸点:
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712.9±60.0 °C(Predicted)
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密度:
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1.345±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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9.47±0.40(Predicted)
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DUOCARMYCIN性质、用途与生产工艺
Duocarmycin DM free base 是一种 DNA 小沟烷基化剂 (DNA minor-groove alkylator)，是一种抗体药物结合物 (ADCs) 毒素。Duocarmycin DM free base 因特有的结构而具有抗癌活性。
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Daunorubicins/Doxorubicins
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The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from
Streptomyces sp.
that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture.
Duocarmycin shows cytotoxicity to several human cancer cells, with IC
50
of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively.
DUOCARMYCIN
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-128915 | Duocarmycin DM free base | | 1 mg | 3520元 |
| 2024/01/25 | HY-128915 | DUOCARMYCIN
Duocarmycin DM free base | 1116745-06-2 | 5mg | 8800元 |
1116745-06-2, DUOCARMYCIN 相关搜索:
- 化合物 T11119
- 1116745-06-2
- Methanone, [(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl][5-[2-(dimethylamino)ethoxy]-1H-indol-2-yl]-
- Duocarmycin DM free base
- DuocarMycin