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(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE
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- CAS号:
- 199596-24-2
- 英文名:
- JIB-04 (NSC 693627) -Z
- 英文别名:
- Z-JIB-04;JIB-04 (Z);JIB-04 Z-isomer;NSC 693627;Z-JIB-04;Z-JIB-04 (NSC 693627);JIB-04 (NSC 693627) -Z;5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine;(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE;(Z)-1-(5-Chloropyridin-2-yl)-2-(phenyl(pyridin-2-yl)methylene)hydrazine;Methanone, phenyl-2-pyridinyl-, 2-(5-chloro-2-pyridinyl)hydrazone, (Z,Z)-
- 中文名:
- (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE
- 中文别名:
- 化合物Z-JIB-04
- CBNumber:
- CB42722687
- 分子式:
- C17H13ClN4
- 分子量:
- 308.76
- MOL File:
- 199596-24-2.mol
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(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE化学性质
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沸点:
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472.9±55.0 °C(Predicted)
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密度:
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1.24±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 6 mg/mL (19.43 mM)
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酸度系数(pKa):
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11.00±0.10(Predicted)
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(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE性质、用途与生产工艺
Z-JIB-04 (NSC 693627, JIB-04 Z-isomer)是JIB-04的异构体。JIB-04 是一种泛选择性的 Jumonji histone demethylase 抑制剂,对于JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC50值分别为230 nM、340 nM、855 nM、445 nM、435 nM、1100 nM和290 nM。
Target | Value |
JARID1A
(Cell-free assay)
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230 nM
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JMJD2D
(Cell-free assay)
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290 nM
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JMJD2E
(Cell-free assay)
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340 nM
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JMJD2B
(Cell-free assay)
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435 nM
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JMJD2A
(Cell-free assay)
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445 nM
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JIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes .
(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-107842 | (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE (Z)-JIB-04 | 199596-24-2 | 5mg | 950元 |
2024/01/25 | HY-107842 | (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE (Z)-JIB-04 | 199596-24-2 | 10mg | 1600元 |
(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE
生产厂家
199596-24-2, (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂,天然产物
- 小分子抑制剂
- 化合物Z-JIB-04
- 199596-24-2
- inhibit,NSC-693627,NSC693627,family,Inhibitor,Jumonji,(Z)JIB04,histone,(Z) JIB 04,JIB-04,demethylases,isomer
- 5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
- NSC 693627;Z-JIB-04
- JIB-04 Z-isomer
- Methanone, phenyl-2-pyridinyl-, 2-(5-chloro-2-pyridinyl)hydrazone, (Z,Z)-
- (Z)-1-(5-Chloropyridin-2-yl)-2-(phenyl(pyridin-2-yl)methylene)hydrazine
- JIB-04 (Z)
- Z-JIB-04
- Z-JIB-04 (NSC 693627)
- JIB-04 (NSC 693627) -Z
- (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE