1982372-88-2
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- CAS号:
- 1982372-88-2
- 英文名:
- A-196
- 英文别名:
- A-196;SGC A-196;A-196
(A196;A-196;A 196;A196;A196,Histone Methyltransferase,A-196,Inhibitor,inhibit;6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine;6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine;1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-
- 中文名:
- 1982372-88-2
- 中文别名:
- 化合物A196;A-196游离态;A 196,SUV420H1 / H2抑制剂;6,7-二氯-N-环戊基-4-(吡啶-4-基)酞嗪-1-胺;SUV420H1和SUV420H2化学抑制剂(A-196)
- CBNumber:
- CB43051065
- 分子式:
- C18H16Cl2N4
- 分子量:
- 359.25
- MOL File:
- 1982372-88-2.mol
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1982372-88-2化学性质
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沸点:
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584.6±45.0 °C(Predicted)
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密度:
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1.399±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO (up to 5 mg/ml)
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酸度系数(pKa):
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3.96±0.30(Predicted)
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形态:
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powder
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颜色:
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white to light brown
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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1982372-88-2性质、用途与生产工艺
A-196 是一种有效的选择性的 SUV420H1 和 SUV420H2 抑制剂,其 IC50 值分别为 25 nM 和 144 nM。A-196 以底物竞争性方式抑制 SUV4-20,也是一种 SUV4-20 的化学探针,用于研究组蛋白甲基转移酶在基因组完整性中的作用。
IC50: 25 nM (SUV420H1) and 144 nM (SUV420H2).
A-196 (0-5 μM; 48 hours; U2OS cells) treatment results in an increase in H4K20me1 (
EC
50
value of 735 nM) and a decrease in both H4K20me2 and H4K20me3 (
EC
50
values of 262 and 370 nM, respectively).
A-196 (10 μM; 72 hours; Wild-type, Suv4-20h double knockout and inhibitortreated mouse embryonic fibroblast cells) inhibits both SUV4-20 enzymes in cells in multiple tissue types without overt toxicity.
Western Blot Analysis
Cell Line:
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U2OS cells
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Concentration:
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0 μM, 0.075 μM, 0.15 μM, 0.3 μM, 0.6 μM, 1.25 μM, 2.5 μM, 5 μM
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Incubation Time:
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48 hours
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Result:
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Increased in H4K20me1 and decreased in both H4K20me2 and H4K20me3.
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1982372-88-2
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100201 | A-196 | | 1 mg | 500元 |
2024/08/19 | HY-100201 | 1982372-88-2 A-196 | 1982372-88-2 | 10mM * 1mLin DMSO | 869元 |
1982372-88-2, 1982372-88-2 相关搜索:
- 合成有机化合物配体
- 对照品
- 细胞生物学试剂
- A 196,SUV420H1 / H2抑制剂
- 6,7-二氯-N-环戊基-4-(吡啶-4-基)酞嗪-1-胺
- 化合物A196
- A-196游离态
- SUV420H1和SUV420H2化学抑制剂(A-196)
- 1982372-88-2
- A196,Histone Methyltransferase,A-196,Inhibitor,inhibit
- A-196;A 196;A196
- A-196
(A196
- 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
- 1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-
- SGC A-196
- 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine
- A-196