1502816-23-0
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- CAS号:
- 1502816-23-0
- 英文名:
- MS049
- 英文别名:
- MS049;MS049 2HCl;MS049 diHCl;MS049;MS-049;MS 049;2-[4-(benzyloxy)piperidin-1-yl]ethyl}(methyl)amine;2-(4-(Benzyloxy)piperidin-1-yl)-N-methylethanamine;1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-;MS-049,arginine,Histone Methyltransferase,MS 049,HEK293,dimethylation,Inhibitor,toxic,H4R3me2a,MS049,inhibit,selective,epigenetic,cells,modifiers
- 中文名:
- 1502816-23-0
- 中文别名:
- 化合物MS049;PRMT4和PRMT6双重抑制剂(MS049);2-(4-(苄氧基)哌啶-1-基)-N-甲基乙胺
- CBNumber:
- CB43128918
- 分子式:
- C15H24N2O
- 分子量:
- 248.36
- MOL File:
- 1502816-23-0.mol
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1502816-23-0化学性质
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沸点:
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352.6±37.0 °C(Predicted)
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密度:
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1.03±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: ≥ 31 mg/mL (124.82 mM)
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酸度系数(pKa):
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10.48±0.10(Predicted)
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1502816-23-0性质、用途与生产工艺
MS049 是一种高效、选择性和细胞活性的 PRMT4 和 PRMT6 双重抑制剂，IC50 分别为 34 nM 和 43 nM。MS049 降低了 HEK293 细胞的 Med12me2a 和 H3R2me2a 水平。MS049 对 HEK293 细胞无毒，并且没有影响其的生长。
IC50: 34 nM (PRMT4), 43 nM (PRMT6)
MS049 (0.1-10 μM; 20 hours) reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC
50
=0.97±0.05 μM).
MS049 (0.1-100 μM; 72 hours) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC
50
=1.4±0.1 μM) in HEK293 cells.
MS049 is selective for PRMT4 and PRMT6 over a broad range of epigenetic modifiers, including other PRMTs, PKMTs, DNMTs, KDMs, and methyllysine/methylarginine reader proteins, and non-epigenetic targets.
Western Blot Analysis
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Cell Line:
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HEK293 cells
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Concentration:
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0.1, 1, 10 μM
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Incubation Time:
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20 hours
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Result:
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Reduced the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC
50
=0.97±0.05 μM).
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Western Blot Analysis
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Cell Line:
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HEK293 cells
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Concentration:
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0.1, 1, 10, 100 μM
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Incubation Time:
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72 hours
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Result:
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Reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC
50
=1.4±0.1 μM) in HEK293 cells.
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1502816-23-0
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100360 | 1502816-23-0
MS049 | 1502816-23-0 | 5mg | 660元 |
| 2024/01/25 | HY-100360 | 1502816-23-0
MS049 | 1502816-23-0 | 10mM * 1mLin DMSO | 726元 |
1502816-23-0, 1502816-23-0 相关搜索:
- 天然产物
- 细胞生物学试剂
- 502816-23-0
- 2-(4-(苄氧基)哌啶-1-基)-N-甲基乙胺
- 化合物MS049
- PRMT4和PRMT6双重抑制剂(MS049)
- 1502816-23-0
- MS-049,arginine,Histone Methyltransferase,MS 049,HEK293,dimethylation,Inhibitor,toxic,H4R3me2a,MS049,inhibit,selective,epigenetic,cells,modifiers
- MS049 diHCl
- 2-(4-(Benzyloxy)piperidin-1-yl)-N-methylethanamine
- 1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-
- MS049;MS-049;MS 049
- 2-[4-(benzyloxy)piperidin-1-yl]ethyl}(methyl)amine
- MS049 2HCl
- MS049