Iodophenpropit dihydrobromide
|
|
|
- CAS号:
- 145196-87-8
- 英文名:
- Iodophenpropit dihydrobromide
- 英文别名:
- Iodophenpropit hydrobromide
- 中文名:
- Iodophenpropit dihydrobromide
- 中文别名:
- 化合物 T15590
- CBNumber:
- CB43146309
- 分子式:
- C15H20BrIN4S
- 分子量:
- 495.22
- MOL File:
- 145196-87-8.mol
|
|
|
Iodophenpropit dihydrobromide化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO:50.0(Max Conc. mg/mL);86.79(Max Conc. mM)
Water:32.2(Max Conc. mg/mL);55.89(Max Conc. mM)-
|
-
形态:
-
Powder
-
|
-
水溶解性:
-
Soluble to 25 mM in water
-
|
Iodophenpropit dihydrobromide性质、用途与生产工艺
Iodophenpropit dihydrobromide 是一种有效的选择性组胺 H3 受体 (histamine H3 receptor) 拮抗剂。[125I] Iodophenpropit 结合 H3 受体具有选择性，可饱和，易于可逆，及高亲和力 (KD 为 0.32 nM)。
|
H
3
Receptor
0.32 nM (Kd)
|
Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor.
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC
50
of 1.57±0.3 μM.
Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits.
|
Animal Model:
|
New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg
|
|
Dosage:
|
1 μg/kg
|
|
Administration:
|
Administered through intramuscular (i.m.); b.i.d.; for 10 days
|
|
Result:
|
Could influence a detectable antibody response to SRBC.
|
Iodophenpropit dihydrobromide
上下游产品信息
上游原料
下游产品
Iodophenpropit dihydrobromide
生产厂家
145196-87-8, Iodophenpropit dihydrobromide 相关搜索:
- 化合物 T15590
- 145196-87-8
- Iodophenpropit hydrobromide