3-羟基-2-吡咯烷酮
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- CAS号:
- 298708-79-9
- 英文名:
- BAY41-4109 Racemic
- 英文别名:
- BAY41-4109 Racemic;Bay 41-4109 (racemate);BAY41-4109 RACEMATE; BAY-41-4109 RACEMATE;Bay 41-4109,Inhibitor,HBV,Bay 41 4109 racemate,inhibit,Bay 414109 racemate,Hepatitis B virus;Methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate;5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester;4-?(2-Chloro-?4-?fluorophenyl)?-?2-?(3,?5-?difluoro-?2-?pyridinyl)?-?1,?4-?dihydro-?6-?methyl-?5-?pyrimidinecarboxylic Acid Methyl Ester
- 中文名:
- 3-羟基-2-吡咯烷酮
- 中文别名:
- BAY41-4109外消旋酒石酸盐
- CBNumber:
- CB43163733
- 分子式:
- C18H13ClF3N3O2
- 分子量:
- 395.76
- MOL File:
- 298708-79-9.mol
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3-羟基-2-吡咯烷酮化学性质
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO:89.5(Max Conc. mg/mL);226.14(Max Conc. mM)
Ethanol:11.0(Max Conc. mg/mL);27.79(Max Conc. mM)-
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形态:
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A crystalline solid
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3-羟基-2-吡咯烷酮性质、用途与生产工艺
BAY 41-4109 racemate (BAY41-4109 Racemic)是 BAY 41-4109的R-异构体和S-异构体的混合物。BAY 41-4109 是一种可抑制 human hepatitis B virus (HBV)的抗病毒化合物，其IC50值为53 nM。
| Target | Value |
HBV capsid
(Cell-free assay)
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53 nM
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BAY 41-4109 is able to both accelerate and misdirect capsid assembly
in vitro
. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC
50
s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production
in vivo
by a mechanism that targets the viral capsid.
3-羟基-2-吡咯烷酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100029A | Bay 41-4109 racemate | | 1 mg | 266元 |
| 2024/01/25 | HY-100029A | 3-羟基-2-吡咯烷酮
Bay 41-4109 racemate | 298708-79-9 | 5mg | 700元 |
298708-79-9, 3-羟基-2-吡咯烷酮 相关搜索:
- API
- BAY41-4109外消旋酒石酸盐
- 298708-79-9
- Bay 41-4109,Inhibitor,HBV,Bay 41 4109 racemate,inhibit,Bay 414109 racemate,Hepatitis B virus
- 4-?(2-Chloro-?4-?fluorophenyl)?-?2-?(3,?5-?difluoro-?2-?pyridinyl)?-?1,?4-?dihydro-?6-?methyl-?5-?pyrimidinecarboxylic Acid Methyl Ester
- 5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester
- BAY41-4109 RACEMATE; BAY-41-4109 RACEMATE
- Methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
- Bay 41-4109 (racemate)
- BAY41-4109 Racemic