1252679-52-9
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- CAS号:
- 1252679-52-9
- 英文名:
- ITX-5061 HCl
- 英文别名:
- ITX-5061;ITX506 HCl;ITX-5061 HCl;ITX-5061 hydrochloride;ITX-5061 hydrochloride
(ITX5061)
- 中文名:
- 1252679-52-9
- 中文别名:
- 化合物 T15603
- CBNumber:
- CB43333732
- 分子式:
- C30H38ClN3O7S
- 分子量:
- 620.16
- MOL File:
- 1252679-52-9.mol
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1252679-52-9化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 83.3 mg/mL (134.32 mM)
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1252679-52-9性质、用途与生产工艺
ITX5061 是 一个 II 型 p38 MAPK 抑制剂，也是清道夫受体 B1 (SR-B1) 的拮抗剂。
ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P<0.05), while calculated production rates are identical in both groups (129±24 μg/g/d vs 129±16 μg/g/d). Moreover, accumulation of [
3
H] CE in the liver is significantly lower in ITX5061-treated mice indicating that increased HDL-CE levels are due to reduced uptake by the liver.
1252679-52-9
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-19900 | ITX5061 | | 1 mg | 2600元 |
| 2024/01/25 | HY-19900 | 1252679-52-9
ITX5061 | 1252679-52-9 | 5mg | 6500元 |
1252679-52-9, 1252679-52-9 相关搜索:
- 化合物 T15603
- 1252679-52-9
- ITX506 HCl
- ITX-5061 hydrochloride
- ITX-5061 hydrochloride
(ITX5061)
- ITX-5061
- ITX-5061 HCl