(R)-GNE-140
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- CAS号:
- 2003234-63-5
- 英文名:
- GNE140
- 英文别名:
- GNE140;CS-2624;(R)-GNE-140;(R)-GNE-140
(GNE-140;GNE-140;GNE 140;GNE140;Inhibitor,LDH,(R) GNE 140,inhibit,Lactate Dehydrogenase,(R)GNE140;(R)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one;2(1H)-Pyridinone, 3-[(2-chlorophenyl)thio]-5,6-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-, (6R)-
- 中文名:
- (R)-GNE-140
- 中文别名:
- 化合物(R)-GNE-140;LDHA抑制剂((R)-GNE-140);(R)-3-((2-氯苯基)硫基)-4-羟基-6-(4-吗啉苯基)-6-(噻吩-3-基)-5,6-二氢吡啶-2(1H)-酮;(6R)-3-[(2-氯苯基)硫代]-5,6-二氢-4-羟基-6-[4-(4-吗啉基)苯基]-6-(3-噻吩基)-2(1H)-吡啶酮
- CBNumber:
- CB43353026
- 分子式:
- C25H23ClN2O3S2
- 分子量:
- 499.04
- MOL File:
- 2003234-63-5.mol
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(R)-GNE-140化学性质
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沸点:
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695.4±55.0 °C(Predicted)
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密度:
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1.46±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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DMSO:14.4(Max Conc. mg/mL);28.9(Max Conc. mM)
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酸度系数(pKa):
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4.50±1.00(Predicted)
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InChIKey:
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SUFXXEIVBZJOAP-RUZDIDTESA-N
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SMILES:
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C1(=O)N[C@](C2=CC=C(N3CCOCC3)C=C2)(C2C=CSC=2)CC(O)=C1SC1=CC=CC=C1Cl
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(R)-GNE-140性质、用途与生产工艺
(R)-GNE-140是选择性的LDHA 和 LDHB抑制剂，IC50分别为3 nM和5 nM。(R)-GNE-140的效力是其S型异构体的18倍。
| Target | Value |
LDHA
(Cell-free assay)
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3 nM
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LDHB
(Cell-free assay)
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5 nM
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(R)-GNE-140 inhibits proliferation in 37 of 347 cancer cell lines tested at a potency cut off of 5 μM. (R)-GNE-140 shows inhibitory effect on two chondrosarcoma (bone) cancer cell lines that harbor IDH1 mutations, with IC
50
of 0.8 μM.
(R)-GNE-140 (5 mg/kg) has high bioavailability in mice. At higher oral doses, ranging from 50 to 200 mg/kg, (R)-GNE-140 displays greater exposure.
(R)-GNE-140
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-100742A | (R)-3-((2-氯苯基)硫基)-4-羟基-6-(4-吗啉苯基)-6-(噻吩-3-基)-5,6-二氢吡啶-2(1H)-酮
(R)-GNE-140 | 2003234-63-5 | 1mg | 909元 |
| 2024/01/25 | HY-100742A | (R)-3-((2-氯苯基)硫基)-4-羟基-6-(4-吗啉苯基)-6-(噻吩-3-基)-5,6-二氢吡啶-2(1H)-酮
(R)-GNE-140 | 2003234-63-5 | 5mg | 2000元 |
2003234-63-5, (R)-GNE-140 相关搜索:
- 药靶配体
- 抑制剂
- 其他生化试剂
- 细胞生物学试剂
- (6R)-3-[(2-氯苯基)硫代]-5,6-二氢-4-羟基-6-[4-(4-吗啉基)苯基]-6-(3-噻吩基)-2(1H)-吡啶酮
- 化合物(R)-GNE-140
- (R)-3-((2-氯苯基)硫基)-4-羟基-6-(4-吗啉苯基)-6-(噻吩-3-基)-5,6-二氢吡啶-2(1H)-酮
- LDHA抑制剂((R)-GNE-140)
- 2003234-63-5
- Inhibitor,LDH,(R) GNE 140,inhibit,Lactate Dehydrogenase,(R)GNE140
- 2(1H)-Pyridinone, 3-[(2-chlorophenyl)thio]-5,6-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-, (6R)-
- CS-2624
- (R)-GNE-140
- (R)-GNE-140
(GNE-140
- (R)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one
- GNE-140;GNE 140;GNE140
- GNE140