1905453-18-0
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- CAS号:
- 1905453-18-0
- 英文名:
- NSC232003
- 英文别名:
- NSC232003;5-(1-(Hydroxyamino)ethylidene)pyrimidine-2,4(3H,5H)-dione;2,4(3H,5H)-Pyrimidinedione, 5-[1-(hydroxyamino)ethylidene]-;E2 conjugating enzyme,Ubiquitin activating enzyme,Inhibitor,NSC 232003,inhibit,E1 activating enzyme,Ubiquitin conjugating enzyme,E1/E2/E3 Enzyme,E3 ligating enzyme,NSC232003,Ubiquitin ligase,NSC-232003
- 中文名:
- 1905453-18-0
- 中文别名:
- 化合物NSC232003;UHRF1抑制剂(NSC232003);5-(1-(羟基氨基)亚乙基)嘧啶-2,4(3H,5H)-二酮
- CBNumber:
- CB43356168
- 分子式:
- C6H7N3O3
- 分子量:
- 169.14
- MOL File:
- 1905453-18-0.mol
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1905453-18-0化学性质
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密度:
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1.60±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Water : 17 mg/mL (100.51 mM);DMSO : < 1 mg/mL (insoluble or slightly soluble)
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酸度系数(pKa):
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9.32±0.20(Predicted)
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1905453-18-0性质、用途与生产工艺
NSC232003 是一种高效的可渗透细胞的 UHRF1 抑制剂，可抑制 DNA 甲基化，并破坏 DNMT1/UHRF1 相互作用。
NSC232003, a uracil derivative freely available by the NCI/DTP repository, provides a versatile lead for developing highly potent and cell-permeable UHRF1 inhibitors that will enable dissection of DNA methylation inheritance. NSC232003 is indeed an effective DNA methylation inhibitor and indicate that this particular nucleotide scaffold could provide a versatile basis for the design of potent UHRF1 inhibitors. NSC232003 is predicted to be partially deprotonated at pH 7, as the pK
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of the more acidic imide nitrogen of the pyrimidine ring is a value of 7.6 in NSC232003. The DNMT1/UHRF1 interactions are significantly reduced after 4 h of incubation of U251 glioma cells with the most potent compound NSC232003, showing a 50% interaction inhibition at 15 μM as well as induction of global DNA cytosine demethylation as measured by ELISA.
1905453-18-0
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-103236 | 1905453-18-0
NSC232003 | 1905453-18-0 | 1mg | 900元 |
| 2024/01/25 | HY-103236 | 1905453-18-0
NSC232003 | 1905453-18-0 | 10mM * 1mLin Water | 1674元 |
1905453-18-0, 1905453-18-0 相关搜索:
- 天然产物
- 细胞生物学试剂
- 5-(1-(羟基氨基)亚乙基)嘧啶-2,4(3H,5H)-二酮
- 化合物NSC232003
- UHRF1抑制剂(NSC232003)
- 1905453-18-0
- 2,4(3H,5H)-Pyrimidinedione, 5-[1-(hydroxyamino)ethylidene]-
- E2 conjugating enzyme,Ubiquitin activating enzyme,Inhibitor,NSC 232003,inhibit,E1 activating enzyme,Ubiquitin conjugating enzyme,E1/E2/E3 Enzyme,E3 ligating enzyme,NSC232003,Ubiquitin ligase,NSC-232003
- 5-(1-(Hydroxyamino)ethylidene)pyrimidine-2,4(3H,5H)-dione
- NSC232003