CA-4948
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- CAS号:
- 1801343-74-7
- 英文名:
- CA-4948
- 英文别名:
- CA-4948;IRAK4-IN-7;IRAK4-IN-2;CA4948-Analog;CA 4948;CA4948;IRAK4-IN-7 CA-4948;CA 4948, CA-4948, CA4948;IRAK4-IN-7 (CA4948 analog);6'-Amino-N-(2-morpholinooxazolo[4,5-b]pyridin-6-yl)-[2,3'-bipyridine]-6-carboxamide;6'-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3'-bipyridine]-6-carboxamide
- 中文名:
- CA-4948
- 中文别名:
- CA-4949;化合物CA-4948;IRAK4-IN-2;PERFEMIKER]CA-4948,99%;6'-氨基-N-[2-(吗啉-4-基)-[1,3]恶唑并[4,5-B]吡啶-6-基]-[2,3'-联吡啶]-6-甲酰胺;6'-氨基-N-[2-(吗啉-4-基)-[1,3]恶唑并[4,5-B]吡啶-6-基]-[2,3'-联吡啶]-6-甲酰胺;6'-AMINO-N-[2-(4-MORPHOLINYL)OXAZOLO[4,5-B]PYRIDIN-6-YL][2,3'-BIPYRIDINE]-6-CARBOXAMIDE
- CBNumber:
- CB43379998
- 分子式:
- C21H19N7O3
- 分子量:
- 417.42
- MOL File:
- 1801343-74-7.mol
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CA-4948化学性质
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熔点:
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>294°C (dec.)
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密度:
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1.444±0.06 g/cm3(Predicted)
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储存条件:
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-20°C Freezer, Under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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10.41±0.43(Predicted)
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形态:
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Solid
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颜色:
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Pale Yellow to Brown
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InChI:
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InChI=1S/C21H19N7O3/c22-18-5-4-13(11-23-18)15-2-1-3-16(26-15)20(29)25-14-10-17-19(24-12-14)27-21(31-17)28-6-8-30-9-7-28/h1-5,10-12H,6-9H2,(H2,22,23)(H,25,29)
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InChIKey:
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RWIMETUXCNDSLE-UHFFFAOYSA-N
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SMILES:
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C1(C2=CC=C(N)N=C2)=NC(C(NC2=CN=C3N=C(N4CCOCC4)OC3=C2)=O)=CC=C1
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CA-4948性质、用途与生产工艺
IRAK4-IN-2 是一种可逆性激酶抑制剂,在TLR和IL-1R信号级联反应中,调节IRAK4的功能。
用途
一种可逆性激酶抑制剂,在TLR和IL-1R信号级联反应中,调节IRAK4的功能。在体内外实验中,具有良好的药代动力学特征和抗肿瘤活性。
CA-4948 is a potent, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. CA-4948 exhibited the greatest efficacy in four of the five ABC-DLBCL PDX models tested as compared to GBC-DLBCL and ABC/GCB DLBCL PDX models. Furthermore, CA-4948 was efficacious in ABC-DLBCL PDX tumors containing activating mutations in both TLR/IL-1R and BCR signaling pathways (MYD88 and CD79B double mutants).
CA-4948
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-109585 | CA-4948 IRAK4-IN-7 | 1801343-74-7 | 5mg | 900元 |
2024/08/19 | HY-109585 | CA-4948 IRAK4-IN-7 | 1801343-74-7 | 10mM * 1mLin DMSO | 990元 |
1801343-74-7, CA-4948 相关搜索:
- 药靶配体
- 小分子API
- 抑制剂
- CA-4949
- PERFEMIKER]CA-4948,99%
- 6'-氨基-N-[2-(吗啉-4-基)-[1,3]恶唑并[4,5-B]吡啶-6-基]-[2,3'-联吡啶]-6-甲酰胺
- IRAK4-IN-2
- 6'-氨基-N-[2-(吗啉-4-基)-[1,3]恶唑并[4,5-B]吡啶-6-基]-[2,3'-联吡啶]-6-甲酰胺
- 化合物CA-4948
- 6'-AMINO-N-[2-(4-MORPHOLINYL)OXAZOLO[4,5-B]PYRIDIN-6-YL][2,3'-BIPYRIDINE]-6-CARBOXAMIDE
- 1801343-74-7
- 6'-Amino-N-[2-(morpholin-4-yl)-[1,3]oxazolo[4,5-b]pyridin-6-yl]-[2,3'-bipyridine]-6-carboxamide
- IRAK4-IN-2
- ABC-type,large B cell lymphoma,IRAK4,IRAK,lymphoma,DLBCL,IRAK4 IN 7,IL-1R associated kinase,non-Hodgkin,diffuse,IRAK-4-IN-7,Interleukin-1 receptor associated kinase,Inhibitor,IRAK4IN7,inhibit
- IRAK4-IN-7 CA-4948
- 6'-Amino-N-[2-(morpholin-4-yl)-[1,3]oxazolo[4,5-b]pyridin-6-yl]-[2,3'-bipyridine]-6-carboxamide
- 6'-Amino-N-(2-morpholinooxazolo[4,5-b]pyridin-6-yl)-[2,3'-bipyridine]-6-carboxamide
- IRAK4-IN-7 (CA4948 analog)
- CA4948-Analog
- [2,3'-Bipyridine]-6-carboxamide, 6'-amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl]-
- 6'-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3'-bipyridine]-6-carboxamide
- CA 4948;CA4948
- IRAK4-IN-7
- CA 4948, CA-4948, CA4948
- CA-4948