CPD1589
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- CAS号:
- 1883650-95-0
- 英文名:
- CDDO-2-P-Im
- 英文别名:
- CPD1589;CPDB1589;CDDO-2-P-Im;CDDO 3P Im,CDDO3PIm;CDDO-3P-Imidazolide;Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(3-pyridinyl)-1H-imidazol-1-yl]-
- 中文名:
- CPD1589
- 中文别名:
- 化合物 T13603;化合物CDDO-3P-IM
- CBNumber:
- CB43956894
- 分子式:
- C39H46N4O3
- 分子量:
- 618.81
- MOL File:
- 1883650-95-0.mol
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CPD1589化学性质
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沸点:
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771.1±70.0 °C(Predicted)
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密度:
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1.25±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (404.00 mM)
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形态:
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Solid
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酸度系数(pKa):
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3.34±0.12(Predicted)
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颜色:
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White to off-white
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CPD1589性质、用途与生产工艺
CDDO-3P-Im 是 CDDO 咪唑胺类似物,具有化学预防作用。CDDO-3P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。CDDO-3P-Im 是一种具有口服活性的坏死 (necroptosis) 抑制剂,可用于缺血/再灌注 (I/R) 的研究。
CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM.
CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC
50
of 4.3 nM.
Apoptosis Analysis
Cell Line:
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U937 cells
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Concentration:
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30 nM, 100 nM
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Incubation Time:
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4 days
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Result:
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Induced differentiation of U937 cells at 30 nM.
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CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
Animal Model:
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Seven week-old female A/J mice
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Dosage:
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50 mg/kg, 200 mg/kg
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Administration:
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Diet; for 16 weeks
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Result:
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Decreased the number, the size and the severity of tumors.
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CPD1589
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-126379 | CDDO-2P-Im | | 1 mg | 1066元 |
2024/08/19 | HY-126379 | CPD1589 CDDO-2P-Im | 1883650-95-0 | 5mg | 2800元 |
1883650-95-0, CPD1589 相关搜索:
- 抑制剂
- C39H46N4O3
- 化合物CDDO-3P-IM
- 化合物 T13603
- 1883650-95-0
- CDDO 3P Im,CDDO3PIm
- CDDO-2-P-Im
- CPD1589
- CPDB1589
- CDDO-3P-Imidazolide
- Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(3-pyridinyl)-1H-imidazol-1-yl]-