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HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE
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- CAS号:
- 131334-43-5
- 英文名:
- H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
- 英文别名:
- MYELIN PROTEOLIPID PROTEIN (139-151);PLP (HUMAN, BOVINE, DOG, MOUSE, RAT);Myelin Proteolipid Protein (139-151) (1);6:PN:WO2012154215 SEQID:5 unclaimed protein;HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE;H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH;PLP (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT);MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT);LIPOPHILIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT);MYELIN PROTEOLIPID PROTEIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)
- 中文名:
- HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE
- 中文别名:
- 髓鞘蛋白脂蛋白;髓鞘蛋白脂蛋白H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
- CBNumber:
- CB4410067
- 分子式:
- C72H104N20O16S
- 分子量:
- 1537.79
- MOL File:
- 131334-43-5.mol
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HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE化学性质
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沸点:
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1897.4±65.0 °C(Predicted)
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密度:
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1.332±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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3.49±0.10(Predicted)
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形态:
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White to off-white powder.
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颜色:
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White to off-white
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序列:
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H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH
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HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE性质、用途与生产工艺
PLP (139-151) 是髓鞘蛋白脂蛋白 (PLP) 139至151氨基酸片段。用于诱导实验性自身免疫性脑脊髓炎 (EAE)。
Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in
in vitro
proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151).
PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE
上下游产品信息
上游原料
下游产品
HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE
生产厂家
131334-43-5, HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE 相关搜索:
- 多肽
- 目录肽
- 目录多肽
- 标准品
- C72H104N20O16S
- 髓鞘蛋白脂蛋白
- 髓鞘蛋白脂蛋白H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
- 131334-43-5
- PLP (139-151)|Myelin Proteolipid Protein (139-151))|(depMyelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat)
- 6:PN:WO2012154215 SEQID:5 unclaimed protein
- L-Phenylalanine, L-histidyl-L-cysteinyl-L-leucylglycyl-L-lysyl-L-tryptophyl-L-leucylglycyl-L-histidyl-L-prolyl-L-α-aspartyl-L-lysyl-
- L-Phenylalanine,L-histidyl-L-cysteinyl-L-leucylglycyl-L-lysyl-L-tryptophyl-L-leucylglycyl-L-histidyl-L-prolyl-L-a-aspartyl-L-lysyl-
- Lipophilin (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), PLP (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), PLP (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), Lipophilin (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat)
- Myelin Proteolipid Protein (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat)
Lipophilin (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), PLP (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), PLP (139-151) (depalMitoylat
- Myelin Proteolipid Protein (139-151) (1)
- MYELIN PROTEOLIPID PROTEIN (139-151)
- PLP (HUMAN, BOVINE, DOG, MOUSE, RAT)
- PLP (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)
- H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH (HUMAN, BOVINE, DOG, MOUSE, RAT)
- H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
- HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE
- LIPOPHILIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)
- MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT)
- MYELIN PROTEOLIPID PROTEIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)