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ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

ADENOSINE-3
ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
CAS号:
142439-94-9
英文名称:
ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
英文同义词:
RP-CAMPS NA;CAMPS NA RP-ISOMER;RP-CAMPS SODIUM SALT;SP-CYCLIC 3,5-HYDROGEN PHOSPHOROTHIOATE ADENOSINE SODIUM SALT;ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT;ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
中文名称:
ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
中文同义词:
CBNumber:
CB4412021
分子式:
C10H11N5NaO5PS
分子量:
367.25
MOL File:
Mol file

ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT化学性质

安全信息

ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT性质、用途与生产工艺

生物活性

Rp-cAMPS sodium salt,一种 cAMP 的类似物,是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的,竞争性拮抗剂。Rp-cAMPS sodium salt 耐磷酸二酯酶水解。

靶点

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)

体外研究

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.

体内研究

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.

ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 上下游产品信息

上游原料

下游产品


ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 生产厂家

全球有 5家供应商   ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT国内生产厂家
供应商联系电话传真电子邮件国家产品数优势度
北京谨明生物科技有限公司 15801484223   psaitong@jm-bio.com 中国 12910 58
 

142439-94-9, ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 相关搜索:

  • 142439-94-9
  • CAMPS NA RP-ISOMER
  • ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT
  • ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
  • RP-CAMPS SODIUM SALT
  • RP-CAMPS NA
  • SP-CYCLIC 3,5-HYDROGEN PHOSPHOROTHIOATE ADENOSINE SODIUM SALT
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