N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺
|
|
|
- CAS号:
- 329198-87-0
- 英文名:
- N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
- 英文别名:
- C-178;2-Furancarboxamide, N-3-dibenzofuranyl-5-nitro-;N-(3-Dibenzofuranyl)-5-nitro-2-furancarboxamide;N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide;MITA,inhibit,Inhibitor,STING,MPYS,C178,ERIS,C-178,C 178,Stimulator of Interferon Genes,TMEM173
- 中文名:
- N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺
- 中文别名:
- 化合物C-178;STING抑制剂C-178;N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺;N-(3-DIBENZOFURANYL)-5-NITRO-2-FURANCARBOXAMIDE
- CBNumber:
- CB44635440
- 分子式:
- C17H10N2O5
- 分子量:
- 322.27
- MOL File:
- 329198-87-0.mol
|
|
|
N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺化学性质
-
熔点:
-
>225°C (dec.)
-
|
-
沸点:
-
448.3±35.0 °C(Predicted)
-
|
-
密度:
-
1.506±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
Soluble in DMSO (up to 25 mg/ml)
-
|
-
形态:
-
solid
-
|
-
酸度系数(pKa):
-
11.35±0.43(Predicted)
-
|
-
颜色:
-
Orange
-
|
-
稳定性:
-
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
-
|
N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺性质、用途与生产工艺
C-178 是干扰素基因刺激物 (STING) 的共价抑制剂。 它与 STING 上的 Cys91 结合以阻断其棕榈酰化并阻止 TBK1 在 HEK293T 细胞中的募集和磷酸化。 C-178 (0.01-1.25 μM) 在 HEK293 细胞中选择性地降低 STING- 而不是 RIG-I- 或 TBK1- 介导的 IFN-β 报告基因活性。 当以 0.5 μM 的浓度使用时，它还可以防止由环状 di-GMP、双链 DNA 和 LPS 诱导的骨髓衍生巨噬细胞 (BMDM) 中的 Ifnb1 表达增加。
C-178是STING的共价抑制剂，与Cys91共价结合。
C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells.C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1.C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced
Ifnb1
expression in mouse bone marrow-derived macrophages.C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts.
Western Blot Analysis
|
Cell Line:
|
Mouse bone marrow-derived macrophages (BMDMs)
|
|
Concentration:
|
0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM
|
|
Incubation Time:
|
1 hour
|
|
Result:
|
Inhibited CMA-induced p-TBK1 expression as a does dependent manner.
|
RT-PCR
|
Cell Line:
|
Mouse bone marrow-derived macrophages (BMDMs)
|
|
Concentration:
|
1 μM
|
|
Incubation Time:
|
1 hour
|
|
Result:
|
Downregulated
Ifnb1
expression in BMDMs.
|
N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-123963 | N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺
C-178 | 329198-87-0 | 5mg | 1100元 |
| 2024/01/25 | HY-123963 | N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺
C-178 | 329198-87-0 | 10mM * 1mLin DMSO | 1210元 |
N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺
生产厂家
329198-87-0, N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 相关搜索:
- 化合物C-178
- N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺
- STING抑制剂C-178
- N-(3-DIBENZOFURANYL)-5-NITRO-2-FURANCARBOXAMIDE
- 329198-87-0
- MITA,inhibit,Inhibitor,STING,MPYS,C178,ERIS,C-178,C 178,Stimulator of Interferon Genes,TMEM173
- 2-Furancarboxamide, N-3-dibenzofuranyl-5-nitro-
- N-(3-Dibenzofuranyl)-5-nitro-2-furancarboxamide
- C-178
- N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide