BERBERINE CHLORIDE HYDRATE
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- CAS号:
- 68030-18-2
- 英文名:
- Berberine chloride hydrate
- 英文别名:
- BERBERINE CHLORIDE HYDRATE;Natural Yellow 18 chloride hydrate;Berberine hydrochloride monohydrate
- 中文名:
- BERBERINE CHLORIDE HYDRATE
- 中文别名:
- CBNumber:
- CB44797027
- 分子式:
- C20H20ClNO5
- 分子量:
- 389.83
- MOL File:
- 68030-18-2.mol
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BERBERINE CHLORIDE HYDRATE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: ≥ 3.9 mg/mL (10.00 mM); Water: 1.25 mg/mL (3.21 mM)
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BERBERINE CHLORIDE HYDRATE性质、用途与生产工艺
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) 是从中草药黄连中分离出来的一种生物碱，常用作抗生素。Berberine chloride hydrate 诱导活性氧 (ROS) 生成并抑制 DNA 拓扑异构酶 (topoisomerase)。抗肿瘤特性。
Berberine chloride hydrate ( Natural Yellow 18 chloride hydrate; 1.25-160 μM; 72 hours) has potential inhibitory effects on the proliferation of four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29.
Berberine chloride hydrate (1.25-160 μM; 24-72 hours) induces a time- and dose-dependent inhibition of LoVo cell growth.
LoVo cells are exposure to Berberine chloride hydrate (10-80 μM) for 24 h. Cell cycle analysis of 40 μM Berberine-treated LoVo cells by flow cytometry shows accumulation of cells in the G2/M phase.
Berberine chloride hydrate (10-80 μM) suppresses cyclin B1, cdc2 and cdc25c protein expression after 24 h, especially at the dose of 80.0 μM.
Cell Proliferation Assay
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Cell Line:
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Four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29
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Concentration:
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1.25, 2.5, 5, 10, 20, 40, 80, and 160 μM
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Incubation Time:
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72 hours
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Result:
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Inhibited the proliferation of four cell lines. The IC
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ranged from 40.8±4.1 μM (LoVo) to 98.6±2.9 μM (HCT116).
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Cell Proliferation Assay
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Cell Line:
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Colorectal carcinoma cell lines LoVo
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Concentration:
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1.25, 2.5, 5, 10, 20, 40, 80, and 160 μM
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Incubation Time:
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24, 48, 72 hours
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Result:
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Induced a time- and dose-dependent inhibition of cell growth. By 72 h, 160.0 μM induced 71.1±1.9 % growth inhibitions in LoVo cells.
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Cell Cycle Analysis
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Cell Line:
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LoVo cells
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Concentration:
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0, 10, 20, 40, or 80 μM
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Incubation Time:
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24 hours
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Result:
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Exposure to 40.0 μM induced G2/M-phase cell cycle arrest, an increase in the G2/M-phase population and a progressive decline in the G1 population.
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Western Blot Analysis
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Cell Line:
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LoVo cells
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Concentration:
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10, 20, 40, or 80 μM
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Incubation Time:
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24 hours
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Result:
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Suppressed cyclin B1, cdc2 and cdc25c protein expression.
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Berberine chloride hydrate (Natural Yellow 18 chloride hydrate; 10, 30, or 50 mg/kg/day; gastrointestinal gavage; for 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine chloride hydrate at doses of 30 and 50 mg/kg/day taken by gastrointestinal gavage shows inhibitory rates of 33.1% and 45.3% on the human colorectal adenocarcinoma xenograft growth in nude mice.
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Animal Model:
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5-week-old BALB/c nu/nu mice with human colorectal adenocarcinoma LoVo xenografts
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Dosage:
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10, 30, or 50 mg/kg/day
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Administration:
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Gastrointestinal gavage; for 10 consecutive days
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Result:
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Showed inhibitory rates of 33.1 % and 45.3 % at doses of 30 and 50 mg/kg/day.
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BERBERINE CHLORIDE HYDRATE
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-17577 | Berberine chloride hydrate | | 100 mg | 660元 |
| 2024/01/25 | HY-17577 | Berberine chloride hydrate | | 10 mM * 1 mLin DMSO | 726元 |
BERBERINE CHLORIDE HYDRATE
生产厂家
68030-18-2, BERBERINE CHLORIDE HYDRATE 相关搜索:
- 68030-18-2
- BERBERINE CHLORIDE HYDRATE
- Berberine hydrochloride monohydrate
- Natural Yellow 18 chloride hydrate