盐酸氯吡胺
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- CAS号:
- 6170-42-9
- 英文名:
- Chloropyramine hydrochloride
- 英文别名:
- CHLOROPYRAMINE HCL;Chloropyramine HCI;Nilfan;Alergosan;Halopyramine hydrochloride;CHLOROPYRAMINE HYDROCHLORIDE;CHLOROPYRAMINE MONOHYDROCHLORIDE;Chloropyramine hydrochloride salt;3-chloro-2H-pyran-2-amine hydrochloride;N-P-CHLOROBENZYL-N,N-DIMETHYL-N-(2-PYRIDYL)ETHYLENEDIAMINE HYDROCHLORIDE
- 中文名:
- 盐酸氯吡胺
- 中文别名:
- 盐酸氯吡胺;氯吡胺盐酸盐;盐酸氯吡胺盐;氯吡拉敏盐酸盐;N-对氯苄基-N′,N′-二甲基-N-(2-吡啶基)乙二胺;N-(4-氯苄基)-N,N’-二甲基-N-2-吡啶基-1,2-乙二胺;N-(4-氯苄基)-N',N'-二甲基-N-2-吡啶基-1,2-乙二胺盐酸盐;N1-(4-氯苄基)-N2,N2-二甲基-N1-(吡啶-2-基)乙烷-1,2-二胺盐酸盐
- CBNumber:
- CB4495475
- 分子式:
- C16H21Cl2N3
- 分子量:
- 326.26
- MOL File:
- 6170-42-9.mol
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盐酸氯吡胺化学性质
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熔点:
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172-174°
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
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颜色:
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White to Off-White
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CAS 数据库:
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6170-42-9(CAS DataBase Reference)
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盐酸氯吡胺性质、用途与生产工艺
Chloropyramine hydrochloride 是一种组胺受体 H1 (histamine receptor H1) 拮抗剂，它也能抑制 VEGFR-3 和 FAK 的生化功能。
BT474 cells are highly sensitive to Chloropyramine hydrochloride (compound 1) treatment, whereby 1 µM concentrations cause a 40% reduction of viability after 48 h of treatment. It is found that at 1 µM concentrations of Chloropyramine hydrochloride, viability of control MCF7-pcDNA3 cells is significantly higher than the viability of MCF7-VEGFR-3 cells (P<0.01) and at 10 µM concentration this difference reaches twofold (P<0.001). In the BT474 cells treatment with Chloropyramine hydrochloride also leads to a concentration-dependent decrease of cell proliferation. When treatment with Chloropyramine hydrochloride is continued for 48 h, the breast cancer cells that overexpressed VEGFR-3 undergo apoptosis. This effect is dose-dependent, with 10 µM Chloropyramine hydrochloride inducing apoptosis in more than 60% of BT474 cells. In our model cell lines MCF7-pcDNA3 and MCF7-VEGFR-3, treatment with 10 µM Chloropyramine hydrochloride for 48 h leads to a 4-fold increase in apoptotic cell death in the cell line that overexpressed VEGFR-3 (18% versus 76 % respectively).
Chloropyramine hydrochloride causes a dramatic reduction of tumor growth in both model systems whereby the tumor size in the treated groups is approximately 20% of the tumor size in vehicle control groups. Doxorubicin administered at 3 mg/kg causes approximately 60% reduction of tumor growth, but has no effect on tumor growth at 0, 3 mg/kg. In contrast, there is a modest effect of Chloropyramine hydrochloride alone (50% reduction of tumor growth). The low-dose combination of Chloropyramine hydrochloride and doxorubicin has a prolonged anti-tumor effect (85% reduction of tumor growth) that is greater than either drug alone.
化学性质
类白色至白色结晶性粉末。熔点168-172℃。
用途
抗过敏药。
用途
抗过敏原料药
盐酸氯吡胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-B1305 | 盐酸氯吡胺
Chloropyramine hydrochloride | 6170-42-9 | 50mg | 600元 |
| 2024/01/25 | HY-B1305 | 盐酸氯吡胺
Chloropyramine hydrochloride | 6170-42-9 | 10mM * 1mLin DMSO | 660元 |
盐酸氯吡胺
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6170-42-9, 盐酸氯吡胺 相关搜索:
- 高端化学
- 医药原料
- 小分子抑制剂
- CH
- Analytical Standards
- Analytical Chromatography Product Catalog
- Alphabetic
- C16H20ClN3ClH
- C16H20ClN3HCl
- N1-(4-氯苄基)-N2,N2-二甲基-N1-(吡啶-2-基)乙烷-1,2-二胺盐酸盐
- 盐酸氯吡胺盐
- N-对氯苄基-N′,N′-二甲基-N-(2-吡啶基)乙二胺
- 氯吡拉敏盐酸盐
- 氯吡胺盐酸盐
- N-(4-氯苄基)-N,N’-二甲基-N-2-吡啶基-1,2-乙二胺
- 盐酸氯吡胺
- N-(4-氯苄基)-N',N'-二甲基-N-2-吡啶基-1,2-乙二胺盐酸盐
- 6170-42-9
- N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine,hydrochloride
- Vascular endothelial growth factor receptor,FAK,inhibit,PTK2,Chloropyramine hydrochloride,VEGFR,Chloropyramine,Focal adhesion kinase,PTK2 protein tyrosine kinase 2,Histamine Receptor,Inhibitor
- Chloropyramine HCI
- CHLOROPYRAMINE HCL
- Alergosan
- Halopyramine hydrochloride
- Nilfan
- Chloropyramine hydrochloride salt
- 3-chloro-2H-pyran-2-amine hydrochloride
- N-[(4-chlorophenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-1,2-ethanediamine
- N1-(4-Chlorobenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine hydrochloride
- N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]LETHYLENEDIAMINE HYDROCHLORIDE
- N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]ETHYLENEDIAMINE HYDROCHLORIDE
- N-P-CHLOROBENZYL-N,N-DIMETHYL-N-(2-PYRIDYL)ETHYLENEDIAMINE HYDROCHLORIDE
- CHLOROPYRAMINE MONOHYDROCHLORIDE
- CHLOROPYRAMINE HYDROCHLORIDE