利拉利汀钠盐
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- CAS号:
- 148554-65-8
- 英文名:
- SECO RAPAMYCIN SODIUM SALT
- 英文别名:
- Secosirolimus;Secorapamycin Na salt;SECORAPAMYCIN A MONOSODIUM;SECO RAPAMYCIN SODIUM SALT;seco Rapamycin Sodium Salt, >85% By HPLC;(19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC);(19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)
- 中文名:
- 利拉利汀钠盐
- 中文别名:
- 色拉帕霉素;利拉利汀钠盐;化合物 T19558;SECO雷帕霉素钠盐;(19E/Z)-SECO RAPAMYCIN SODIUM SALT (~80% BY HPLC)
- CBNumber:
- CB4501000
- 分子式:
- C51H80NNaO13
- 分子量:
- 938.18
- MOL File:
- 148554-65-8.mol
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利拉利汀钠盐化学性质
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熔点:
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120-122°C
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储存条件:
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Amber Vial, -20°C Freezer, Under Inert Atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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Pale Yellow to Yellow
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稳定性:
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Light Sensitive
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利拉利汀钠盐性质、用途与生产工艺
Seco Rapamycin sodium salt 是 Rapamycin 的开环代谢物。Seco-Rapamycin 几乎不影响 mTOR 功能。
Disposition of Seco Rapamycin in Human Tissue Homogenates and Caco-2 Cell Monolayers. To determine whether Seco Rapamycin (D2) can be metabolized to dihydro Sirolimus (M2), 20 μM Seco Rapamycin is incubated with human liver, jejunal mucosal, and Caco-2 homogenates. All of these homogenates produced M2 in an NADPH-dependent manner. Ketoconazole, at a high concentration (100 μM), has no effect on the formation of M2 in any of the homogenates examined. To determine whether Seco Rapamycin can be metabolized to M2 in intact cells, 20 μM Seco Rapamycin is added to Caco-2 cell monolayers. When applied to the apical compartment, little Seco Rapamycin is detected in the basolateral compartment and in the cellular fraction after 4 h. In addition, little M2 is detected. LY335979 has little effect on the distribution of Seco Rapamycin after an apical dose, although M2 became detectable in the apical compartment. In contrast, when Seco Rapamycin is applied to the basolateral compartment, both Seco Rapamycin and M2 are readily detected in the apical compartment; LY335679 decreases the flux of Seco Rapamycin to the apical compartment and increases the amount of M2 in both apical and basolateral compartments.
利拉利汀钠盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-19555A | Seco Rapamycin sodium salt | | 1 mg | 1590元 |
| 2024/01/25 | HY-19555A | 利拉利汀钠盐
Seco Rapamycin sodium salt | 148554-65-8 | 5mg | 3500元 |
148554-65-8, 利拉利汀钠盐 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Impurities
- Heterocycles
- Chiral Reagents
- Various Metabolites and Impurities
- Metabolites & Impurities
- C51H78NNaO13
- 色拉帕霉素
- 化合物 T19558
- SECO雷帕霉素钠盐
- 利拉利汀钠盐
- (19E/Z)-SECO RAPAMYCIN SODIUM SALT (~80% BY HPLC)
- 148554-65-8
- Secosirolimus
- Secorapamycin Na salt
- (19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC)
- (19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)
- SECORAPAMYCIN A MONOSODIUM
- SECO RAPAMYCIN SODIUM SALT
- seco Rapamycin Sodium Salt, >85% By HPLC