BOHEMINE
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- CAS号:
- 189232-42-6
- 英文名:
- BOHEMINE
- 英文别名:
- 3-{[6-(Benzylamino)-9-Isopropyl-9H-Purin-2-Yl]Amino}-1-Propanol;3-((6-(benzylaMino)-9-isopropyl-9H-purin-2-yl)aMino)propan-1-ol;1-Propanol,3-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-;CDK,MAb,inhibit,rearrangement,Bohemine,proteosynthesis,Extracellular signal regulated kinases,Inhibitor,Cyclin dependent kinase,dk9/cyclin T1,ERK,cytoskeleton,Cdk2/cyclin A,purine,anti-cancer,Cdk2/cyclin E
- 中文名:
- BOHEMINE
- 中文别名:
- 化合物BOHEMINE;3-((6-(苄基氨基)-9-异丙基-9H-嘌呤-2-基)氨基)丙-1-醇;3-{[6-(苄基氨基)-9-异丙基-9H-嘌呤-2-基]氨基}-1-丙醇
- CBNumber:
- CB4503170
- 分子式:
- C18H24N6O
- 分子量:
- 340.42
- MOL File:
- 189232-42-6.mol
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BOHEMINE化学性质
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熔点:
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101-103 °C
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沸点:
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589.4±60.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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chloroform: 50 mg/mL, soluble
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形态:
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powder
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酸度系数(pKa):
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14.94±0.10(Predicted)
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BOHEMINE性质、用途与生产工艺
Bohemine是CDK抑制剂，对Cdk2/cyclin E, Cdk2/cyclin A和Cdk9/cyclin T1的IC50值分别为4.6, 83和2.7 μM。
| Target | Value |
Cdk9/cyclin T1
()
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2.7 μM
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Cdk2/cyclin E
()
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4.6 μM
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Cdk2/cyclin A
()
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83 μM
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Bohemine (0-30 µM; 72 hours; ME-750 cells) treatment inhibits cell growth. Addition of Bohemine at concentrations in the range of 1-10 µM results in a short-term arrest of growth and of monoclonal antibody production. The short-term suppression of cell functions is followed by a significant temporary increase of specific growth rate and of specific production rate.
Hybridoma cells are retarded both at the G1/S boundary and at the G2/M boundary, depending on Bohemine (0-30 µM) concentration.
T-lymphoblastic cell line CEM is treated by Bohemine, five proteins are found to be downregulated, namely α-enolase, triosephosphate isomerase, initiation factor 5A, and α- and β-subunits of Rho GDP-dissociation inhibitor 1. These proteins play significant roles in glycolysis, proteosynthesis, and in cytoskeleton rearrangement.
Bohemine inhibits growth of human tumor cell lines with an IC
50
of 27 µM.
Cell Viability Assay
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Cell Line:
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Mouse hybridoma ME-750 cells
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Concentration:
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0 µM, 1 µM, 3 µM, 10 µM and 30 µM
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Incubation Time:
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72 hours
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Result:
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At 10 µM and 30 µM concentrations, the viable cell count was significantly lower with respect to control, i.e., 77% and 48%, respectively.
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Bohemine (50 mg/kg; intravenous injection; BALB/c mice) treatment shows C
max
is 72,308 nM, observed clearance is 0.23 L/h and T
1/2
is 1.39 h.
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Animal Model:
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BALB/c mice bearing the colon 26 murine tumor
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Dosage:
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50 mg/kg
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Administration:
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Intravenous injection (Pharmacokinetic Analysis)
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Result:
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C
max
is 72,308 nM, observed clearance is 0.23 L/h and T
1/2
is 1.39 h.
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BOHEMINE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | S6531 | BOHEMINE
Bohemine | 189232-42-6 | 5mg | 794.57元 |
| 2024/01/16 | S6531 | BOHEMINE
Bohemine | 189232-42-6 | 25mg | 2432.89元 |
189232-42-6, BOHEMINE 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 小分子抑制剂，天然产物
- 小分子抑制剂
- C18H24N6O
- 化合物BOHEMINE
- 3-((6-(苄基氨基)-9-异丙基-9H-嘌呤-2-基)氨基)丙-1-醇
- 3-{[6-(苄基氨基)-9-异丙基-9H-嘌呤-2-基]氨基}-1-丙醇
- 189232-42-6
- CDK,MAb,inhibit,rearrangement,Bohemine,proteosynthesis,Extracellular signal regulated kinases,Inhibitor,Cyclin dependent kinase,dk9/cyclin T1,ERK,cytoskeleton,Cdk2/cyclin A,purine,anti-cancer,Cdk2/cyclin E
- 1-Propanol,3-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
- 3-{[6-(Benzylamino)-9-Isopropyl-9H-Purin-2-Yl]Amino}-1-Propanol
- 3-((6-(benzylaMino)-9-isopropyl-9H-purin-2-yl)aMino)propan-1-ol