5-甲氧基黄酮
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- CAS号:
- 42079-78-7
- 英文名:
- 5-METHOXYFLAVONE
- 英文别名:
- 5-METHOXYFLAVONE;METHOXYFLAVONE, 5-;5-Methoxyflavone>5-Methoxy flavonone;5-Methoxyflavone,97%;5-methoxy-2-phenyl-chromone;5-methoxy-2-phenylchromen-4-one;5-methoxy-2-phenyl-4-benzopyrone;5-methoxy-2-phenyl-chromen-4-one;5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
- 中文名:
- 5-甲氧基黄酮
- 中文别名:
- 甲氧基黄酮;5-甲氧基黄酮,97%
- CBNumber:
- CB4688875
- 分子式:
- C16H12O3
- 分子量:
- 252.26
- MOL File:
- 42079-78-7.mol
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5-甲氧基黄酮化学性质
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熔点:
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131-133°C
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沸点:
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422.5±45.0 °C(Predicted)
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密度:
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1,155g/cm
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折射率:
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1,548
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储存条件:
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Store at -20°C
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溶解度:
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soluble in Methanol
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形态:
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powder to crystal
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颜色:
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White to Almost white
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LogP:
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3.470 (est)
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CAS 数据库:
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42079-78-7(CAS DataBase Reference)
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5-甲氧基黄酮性质、用途与生产工艺
5-Methoxyflavone，是一种类黄酮，是DNA聚合酶 β (DNA polymerase-beta) 的抑制剂和 β-淀粉样蛋白毒性的神经保护剂。拥有中枢神经系统镇静剂的作用,通过调控嗜离子 GABAA 受体来实现。
| Target | Value |
DNA polymerase β
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5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. 5-methoxyflavone (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF, 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner.
5-Methoxyflavone (100, 150 mg/kg, i.p) significantly decreases the latency time to loss of righting reflex. 5-Methoxyflavone (50, 100 and 150 mg/kg, i.p) exhibits a significant and dose-dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, i.p) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, i.p) completely abolishesed the grooming response similar to diazepam treated animals.
5-甲氧基黄酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-107790 | 5-甲氧基黄酮
5-Methoxyflavone | 42079-78-7 | 25mg | 500元 |
| 2024/01/25 | HY-107790 | 5-甲氧基黄酮
5-Methoxyflavone | 42079-78-7 | 10mM * 1mLin DMSO | 550元 |
5-甲氧基黄酮
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5-甲氧基黄酮国内生产厂家
42079-78-7, 5-甲氧基黄酮 相关搜索:
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- Mono-substituted Flavones
- 天然产物
- 中药对照品
- 吡喃
- 植物提取物
- Heterocyclic Building Blocks
- Building Blocks
- Benzopyrans
- 甲氧基黄酮
- 5-甲氧基黄酮,97%
- 42079-78-7
- 5 methoxyflavone,5methoxyflavone,Inhibitor,inhibit,DNA/RNA Synthesis,5-Methoxyflavone
- 5-Methoxyflavone>
- 5-Methoxy flavonone
- 4H-1-Benzopyran-4-one, 5-methoxy-2-phenyl-
- 5-methoxy-2-phenyl-chromone
- 5-methoxy-2-phenylchromen-4-one
- 5-methoxy-2-phenyl-chromen-4-one
- 5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
- 5-Methoxyflavone,97%
- 5-methoxy-2-phenyl-4-benzopyrone
- 5-METHOXYFLAVONE
- METHOXYFLAVONE, 5-