2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶
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- CAS号:
- 105650-23-5
- 英文名:
- 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
- 英文别名:
- PHIP;Ccris 2954;Brn 5951264;N,N-diethyl-3-hydroxy-4-methoxybenzamide;Amino-1-methyl-6-phenylimidazo[4.5-b]pyridine;2-AMINO-1-METHYL-6-PHENYLIMADAZO(4,5-B)PYRIDINE;2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE;2-AMINO-1-METHYL-6-PHENOLIMIDAZO[4,5-B]PYRIDINE;2-Amino-1-methyl-6-phenylimidazo[4,5-β]pyridine;5-b)pyridine,2-amino-1-methyl-6-phenyl-imidazo(
- 中文名:
- 2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶
- 中文别名:
- 化合物 T16525;PHIP,致癌杂环胺;2-氨基-1-甲基-6-苯咪唑[4,5-B]吡啶;2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶;2-氨基-1-甲基-6-苯基咪唑并[4,5-B]吡啶;1-甲基-6-苯基-1H-咪唑并[4,5-B]吡啶-2-胺
- CBNumber:
- CB4716839
- 分子式:
- C13H12N4
- 分子量:
- 224.26
- MOL File:
- 105650-23-5.mol
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2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶化学性质
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熔点:
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300
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沸点:
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355.66°C (rough estimate)
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密度:
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1.2067 (rough estimate)
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折射率:
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1.5890 (estimate)
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储存条件:
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Refrigerator
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溶解度:
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DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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7.72±0.30(Predicted)
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CAS 数据库:
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105650-23-5(CAS DataBase Reference)
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(IARC)致癌物分类:
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2B (Vol. 56) 1993
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2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶性质、用途与生产工艺
PhIP 是在熟肉中形成的杂环芳香胺 (HAA)，是一种可能的致癌物。具有 DNA 破坏性和诱变性。 PhIP 还具有雌激素活性，可能有助于其组织特异性致癌性。
PhIP causes widespread and largely over-lapping effects on miRNA expression. PhIP induces widespread effects via activation of oestrogen receptor alpha (ERα). Deregulation of miRNA by PhIP could potentially be an important non-DNA-damaging carcinogenic mechanism in breast cancer.
In hCYP1A-mice, PhIP induces inflammation, epithelial cell damage, and prostatic intraepithelial neoplasia in the dorsolateral prostate lobe compared to the ventral lobe. PhIP forms DNA adducts in the prostate, PhIP also induces oxidative stress, atrophy of the acini, and inflammation of the prostate of rodents.
类别
有毒物品
可燃性危险特性
可燃;燃烧产生有毒氮氧化物烟雾
储运特性
库房通风低温干燥
灭火剂
干粉、泡沫、砂土、二氧化碳, 雾状水
2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-118716 | PhIP | | 1 mg | 2000元 |
| 2024/01/25 | HY-118716 | 2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶
PhIP | 105650-23-5 | 5 mg | 5000元 |
2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶
生产厂家
105650-23-5, 2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶 相关搜索:
- Nucleotides
- Mutagenesis Research Chemicals
- Bases & Related Reagents
- Detergents
- 药靶配体
- C13H12N4
- PHIP,致癌杂环胺
- 2-氨基-1-甲基-6-苯咪唑[4,5-B]吡啶
- 化合物 T16525
- 2-氨基-1-甲基-6-苯基咪唑并[4,5-B]吡啶
- 2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶
- 1-甲基-6-苯基-1H-咪唑并[4,5-B]吡啶-2-胺
- 105650-23-5
- 1H-Imidazo[4,5-b]pyridin-2-amine, 1-methyl-6-phenyl-
- N,N-diethyl-3-hydroxy-4-methoxybenzamide
- 1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine98%
- 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 2-Amino-1-methyl-6-phenyl-4-azabenzimidazole
- 1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine 98%
- 5-b)pyridine,2-amino-1-methyl-6-phenyl-imidazo(
- 5-b)pyridine,2-amino-1-methyl-6-phenyl-1h-imidazo(
- 2-Amino-1-methyl-6-phenylimidazo[4,5-β]pyridine
- 1-Methyl-6-phenyl-1H-imidazo[4,5-β]pyridin-2-amine
- 2-Amino-1-methyl-6-phenylimidazo[4,5,b]pyridine, (PhIP)
- 2-AMINO-1-METHYL-6-PHENOLIMIDAZO[4,5-B]PYRIDINE
- 2-AMINO-1-METHYL-6-PHENYL-1H-IMIDAZO[4,5-B]PYRIDINE
- 2-AMINO-1-METHYL-6-PHENYLIMADAZO(4,5-B)PYRIDINE
- 1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine
- Imidazo(4,5-B)pyridine, 2-amino-1-methyl-6-phenyl-
- Ccris 2954
- Brn 5951264
- 1H-Imidazo(4,5-B)pyridine, 2-amino-1-methyl-6-phenyl-
- 1H-Imidazo(4,5-B)pyridin-2-amine, 1-methyl-6-phenyl- (9ci)
- Amino-1-methyl-6-phenylimidazo[4.5-b]pyridine
- 5-b)pyridin-2-amine,1-methyl-6-phenyl-1h-imidazo(
- PHIP
- 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE