氯氮平-N-氧化物
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- CAS号:
- 34233-69-7
- 英文名:
- CLOZAPINE N-OXIDE
- 英文别名:
- CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);Clozapine N-oxide solution;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW;Clozapine N-oxide (4-oxido-piprazinyl);Clozapine N-Oxide (1.0 mg/mL in Methanol);MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
- 中文名:
- 氯氮平-N-氧化物
- 中文别名:
- 氯氮平一氧化氮;氯氮平氮氧化物;氯氮平N-氧化;氯氮平氮氧化合物;氯氮平EP杂质8;氯氮平 N-氧化物;氯氮平N- OXIDE;氯氮平N-氧化物(氯氮平杂质1);8-氯-4-甲基-5H-二苯并[B,E][1,4]二氮哌嗪;CLOZAPINE N-OXIDE (4-OXIDO-PIPRAZINYL)
- CBNumber:
- CB4759216
- 分子式:
- C18H19ClN4O
- 分子量:
- 342.82
- MOL File:
- 34233-69-7.mol
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氯氮平-N-氧化物化学性质
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熔点:
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190-248°C
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闪点:
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9℃
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储存条件:
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-20°C Freezer, Under Inert Atmosphere
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溶解度:
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Soluble in DMSO.
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形态:
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powder
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酸度系数(pKa):
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6.86±0.20(Predicted)
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颜色:
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Yellow
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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InChIKey:
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OGUCZBIQSYYWEF-UHFFFAOYSA-N
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氯氮平-N-氧化物性质、用途与生产工艺
Clozapine N-oxide (CNO) 是一种 Clozapine (GLXC-06516) 的代谢产物,是 human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs) 的激动剂。Clozapine 是一种有效的 dopamine (DA) 拮抗剂和选择性的 muscarinic M4 receptor 的激动剂。
Target | Value |
DREADD
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Dopamine receptor
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muscarinic M4 receptor
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Clozapine N-oxide (CNO) can bind to non-DREADD receptors at concentrations required for DREADD activation, and undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic that acts at a variety of pharmacological targets and produces numerous physiological and behavioral effects.
After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h).
氯氮平-N-氧化物
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-17366 | 氯氮平-N-氧化物 Clozapine N-oxide | 34233-69-7 | 5mg | 750元 |
2024/01/25 | HY-17366 | 氯氮平-N-氧化物 Clozapine N-oxide | 34233-69-7 | 10mM * 1mLin DMSO | 825元 |
34233-69-7, 氯氮平-N-氧化物 相关搜索:
- Metabolites
- Various Metabolites and Impurities
- 药靶配体
- 原料药
- 杂质对照品
- 抑制剂
- C18H19ClN4O2HCl
- C18H19ClN4O
- 4-(8-氯-5H-二苯并[B,E][1,4]二氮杂卓-1-基)-1-甲基哌嗪 1-氧化物
- 4-(8-氯-5H-二苯并[B,E][1,4]重氮基庚英-11-基)-1-甲基哌嗪 1-氧化
- 氯氮平N-氧化物(氯氮平杂质1)
- 氯氮平一氧化氮
- CLOZAPINE N-OXIDE (4-OXIDO-PIPRAZINYL)
- 氯氮平N- OXIDE
- 8-氯-4-甲基-5H-二苯并[B,E][1,4]二氮哌嗪
- 氯氮平N-氧化
- 氯氮平EP杂质8
- 氯氮平氮氧化物
- 氯氮平 N-氧化物
- 氯氮平氮氧化合物
- 34233-69-7
- 4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
- Clozapine N-Oxide imp
- 3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
- Clozapine Impurity 16
- Clozapine N-OxideQ: What is
Clozapine N-Oxide Q: What is the CAS Number of
Clozapine N-Oxide Q: What is the storage condition of
Clozapine N-Oxide Q: What are the applications of
Clozapine N-Oxide
- 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
- Clozapine N-oxide (4-oxido-piprazinyl)
- Clozapine N-Oxide (1.0 mg/mL in Methanol)
- Clozapine N-oxide dihydrochloride NEW
- Clozapine impurity 5/Clozapine N-Oxide/4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
- 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
- Clozapine N-oxide (CNO)
- Clozapine N-oxide solution
- Clozapine N-oxide Methanol Adduct
- MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
- 8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE
- CLOZAPINE N-OXIDE
- e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide