Nav1.1 activator 1
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- CAS号:
- 2332897-85-3
- 英文名:
- Nav1.1 activator 1
- 英文别名:
- Nav1.1 activator 1;Nav1.1 activator 1,Nav-1.1 activator 1;3-Pyridinecarboxamide, 4-(2,5-difluorophenyl)-2-[(3S)-3-fluoro-1-pyrrolidinyl]-N-[6-(1-methylethyl)-3-pyridinyl]-
- 中文名:
- Nav1.1 activator 1
- 中文别名:
- 化合物 T12179
- CBNumber:
- CB48054470
- 分子式:
- C24H23F3N4O
- 分子量:
- 440.46
- MOL File:
- 2332897-85-3.mol
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Nav1.1 activator 1化学性质
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沸点:
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533.1±50.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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11.63±0.70(Predicted)
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Nav1.1 activator 1性质、用途与生产工艺
Nav1.1 activator 1 (compound 4) 是强有效的、能透过血脑屏障的、 Nav1.1 激动剂，0.03 μM 可增加衰减Nav1.1 电流的时间常数 τ。对 Nav1.2、Nav1.5、Nav1.6 有显著的选择性。
Nav1.1 activator 1 (compound 4) is a valuable Na
v
1.1 activator for further evaluation of pathophysiological functions of the Nav1.1 channel and has potential for therapeutic treatments of CNS diseases such as Dravet syndrome.
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Animal Model:
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Mice.
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Dosage:
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30 mg/kg (
Pharmacokinetic Analysis
).
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Administration:
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IP once (Exposure was measured at 1 h after administration).
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Result:
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Intraperitoneal administration (30 mg/kg) of compound resulted in sufficient brain exposure (193 ng/g 1 h after administration), which corresponded to 13 nM of free brain concentration comparable to the in vitro potency of the compound.
Had a potential use as an in vivo tool to investigate whether this type of Na
v
1.1 activator can restore Na
v
1.1 functions and modify the disease state in animal models.
Could penetrate the blood-brain barrier (BBB) in humans.
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Nav1.1 activator 1
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-126429 | Nav1.1 activator 1 | | 1 mg | 1409元 |
| 2024/04/30 | HY-126429 | Nav1.1 activator 1
Nav1.1 activator 1 | 2332897-85-3 | 5mg | 3100元 |
2332897-85-3, Nav1.1 activator 1 相关搜索:
- 化合物 T12179
- 2332897-85-3
- 3-Pyridinecarboxamide, 4-(2,5-difluorophenyl)-2-[(3S)-3-fluoro-1-pyrrolidinyl]-N-[6-(1-methylethyl)-3-pyridinyl]-
- Nav1.1 activator 1,Nav-1.1 activator 1
- Nav1.1 activator 1