FMK
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- CAS号:
- 821794-92-7
- 英文名:
- 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
- 英文别名:
- FMK;Fluoromethyl Ketone;RSK2 kinase inhibitor;FMK - RSK inhibitor Fmk;Fluoromethyl Ketone-MEA, FMK-MEA;1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone;1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone;Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-;1-[5-amino-9-(3-hydroxypropyl)-7-(4-methylphenyl)-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-8-yl]-2-fluoro-ethanone
- 中文名:
- FMK
- 中文别名:
- 化合物FMK;RSK2抑制剂(FMK);FMK,不可逆核糖体S6激酶1/2抑制剂;1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氟乙酮
- CBNumber:
- CB51161837
- 分子式:
- C18H19FN4O2
- 分子量:
- 342.37
- MOL File:
- 821794-92-7.mol
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FMK化学性质
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密度:
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1.36
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in H2O; ≥17.1 mg/mL in DMSO; ≥28.7 mg/mL in EtOH
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形态:
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solid
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FMK性质、用途与生产工艺
FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。
Pretreatment of ARVMs with 3 μM fmk attenuates the increase in Ser386 phosphorylation, but it has no inhibitory effect on the increase in Thr577 phosphorylation. FMK inhibits relatively few protein kinases in the panel, although it does inhibit protein tyrosine kinases, such as Src, Lck, Yes and Eph-A2, as well as S6K1. FMK will not inhibit RSK if the N-terminal kinase domain are activated by a mechanism that is independent of the C-terminal domain. Fmk potently inactivates the CTD auto-kinase activity of RSK1 and RSK2 with high specificity in mammalian cells. Targeting RSK2 by a specific small molecule RSK inhibitor fmk attenuates FGFR3-induced cytokine-independent growth in Ba/F3 cells. FMK inhibits cytokine-independent proliferation of Ba/F3 cells conferred by FGFR3.
FMK
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FMK
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FMK国内生产厂家
821794-92-7, FMK 相关搜索:
- API
- PI3K
- mTOR
- Akt
- 合成有机化合物配体
- 定做
- 细胞生物学试剂
- FMK,不可逆核糖体S6激酶1/2抑制剂
- 化合物FMK
- RSK2抑制剂(FMK)
- 1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氟乙酮
- 821794-92-7
- Fluoromethyl Ketone-MEA, FMK-MEA
- Fluoromethyl Ketone
- 1-[5-amino-9-(3-hydroxypropyl)-7-(4-methylphenyl)-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-8-yl]-2-fluoro-ethanone
- Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-
- FMK - RSK inhibitor Fmk
- FMK
- RSK2 kinase inhibitor
- 1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone
- 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone