氟甲沙朵
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- CAS号:
- 30914-89-7
- 英文名:
- Flumexadol
- 英文别名:
- 1841CERM;CERM-1841;Flumexadol;2-(α,α,α-Trifluoro-m-tolyl)morpholine;2-[3-(Trifluoromethyl)phenyl]morpholine;Morpholine, 2-[3-(trifluoromethyl)phenyl]-
- 中文名:
- 氟甲沙朵
- 中文别名:
- 氟甲沙朵;化合物 T11302
- CBNumber:
- CB51178778
- 分子式:
- C11H12F3NO
- 分子量:
- 231.21
- MOL File:
- 30914-89-7.mol
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氟甲沙朵化学性质
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沸点:
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132 °C(Press: 10 Torr)
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密度:
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1.2081 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 100 mg/mL (432.51 mM)
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酸度系数(pKa):
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8.41±0.40(Predicted)
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氟甲沙朵性质、用途与生产工艺
Flumexadol 是一种口服活性非麻醉镇痛药。Flumexadol 是一种选择性和亲和力的 5-HT2C 受体激动剂，对于 Flumexadol 的 (+)-对映体，Ki 为 25 nM，选择性是 5-HT2A 受体的 40 倍。
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5-HT
2C
Receptor
25 nM (Ki)
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In rats and dogs dosed with
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C-Flumexadol (CERM1841), the
14
C is excreted in the urine. The
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C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.
氟甲沙朵
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-133024 | 氟甲沙朵
Flumexadol | 30914-89-7 | 5mg | 900元 |
| 2024/01/25 | HY-133024 | 氟甲沙朵
Flumexadol | | 10 mM * 1 mLin DMSO | 990元 |
30914-89-7, 氟甲沙朵 相关搜索:
- 化合物 T11302
- 氟甲沙朵
- 30914-89-7
- Morpholine, 2-[3-(trifluoromethyl)phenyl]-
- CERM-1841
- 2-[3-(Trifluoromethyl)phenyl]morpholine
- 2-(α,α,α-Trifluoro-m-tolyl)morpholine
- 1841CERM
- Flumexadol