蛋白酶体抑制剂
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- CAS号:
- 133343-34-7
- 英文名:
- LACTACYSTIN
- 英文别名:
- Lacta;Aids008388;LACTACYSTIN;Aids-008388;(+)-LACTACYSTIN;LACTACYSTIN (NATIVE);LACTACYSTIN USP/EP/BP;LACTACYSTIN, SYNTHETIC;LACTACYSTIN, STREPTOMYCES SP;S-[2R,3S,4R]-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYROLIDINECARBONYL
- 中文名:
- 蛋白酶体抑制剂
- 中文别名:
- 乳胞素;乳酸胱氨酸;蛋白酶体抑制剂;蛋白酶体抑制剂 5级;(+)-LACTACYSTIN
- CBNumber:
- CB5136696
- 分子式:
- C15H24N2O7S
- 分子量:
- 376.43
- MOL File:
- 133343-34-7.mol
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蛋白酶体抑制剂化学性质
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熔点:
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233-235°C dec.
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沸点:
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714.9±60.0 °C(Predicted)
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密度:
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1.367±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (up to 20 mg/ml), in Water (up to 10 mg/ml), or in Ethanol (up to 1 mg/ml).
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形态:
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powder
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酸度系数(pKa):
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3.11±0.10(Predicted)
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颜色:
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White to off-white
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水溶解性:
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Soluble to 10 mM in water
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used with one working day. Aqueous solutions should not be stored.
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蛋白酶体抑制剂性质、用途与生产工艺
Lactacystin 是一种抗生素，链霉菌属的代谢物，是一种有效的选择性蛋白酶体 (proteasome) 抑制剂，对 20S 蛋白酶体的 IC50 为 4.8 μM。Lactacystin 还抑制溶酶体酶组织蛋白酶 A。Lactacystin 抑制细胞生长并诱导神经突增生。
IC50: 4.8 μM (proteasome)
Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.
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Animal Model:
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Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old
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Dosage:
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2 µg
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Administration:
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Microinjection
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Result:
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Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.
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蛋白酶体抑制剂
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-16594 | Lactacystin | | 50 μg | 1050元 |
| 2024/01/25 | HY-16594 | Lactacystin | | 100 μg | 1700元 |
蛋白酶体抑制剂
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蛋白酶体抑制剂国内生产厂家
133343-34-7, 蛋白酶体抑制剂 相关搜索:
- ProteaseInhibitors
- Protease
- Proteasomes
- Proteasome inhibitorEnzyme Inhibitors by Enzyme
- Proteasome inhibitor
- Protease Inhibitor Specificity Index
- P to
- Nitric Oxide and Cell Stress
- Intracellular Protein Degradation
- InhibitorsProtease Inhibitors
- Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases
- Metabolites
- Inhibitors
- All Inhibitors
- 多肽
- P to Q
- Proteasome inhibitor
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Enzyme
- Enzyme Inhibitors
- BioChemical
- Biochemicals and Reagents
- C15H24N2O7S
- 乳酸胱氨酸
- 蛋白酶体抑制剂 5级
- (+)-LACTACYSTIN
- 蛋白酶体抑制剂
- 乳胞素
- 133343-34-7
- L-Cysteine, N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-
- LACTACYSTIN USP/EP/BP
- Lacta
- N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-Methylpropyl]-4-Methyl-5-oxo-D-prolyl]-L-cysteine
- L-Cysteine, N-acetyl-, (2R,3S,4R)-3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester)
- Aids-008388
- Aids008388
- S-[2R,3S,4R]-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYROLIDINECARBONYL
- (2R)-2-(Acetylamino)-3-[[[(2R,3S,4R)-2-[(1S)-2-methyl-1-hydroxypropyl]-3-hydroxy-4-methyl-5-oxopyrrolidin-2-yl]carbonyl]thio]propionic acid
- (2R)-2-(Acetylamino)-3-[[(2R)-3β-hydroxy-4β-methyl-2-[(S)-1-hydroxy-2-methylpropyl]-5-oxopyrrolidine-2-yl]carbonylthio]propanoic acid
- N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE
- LACTACYSTIN, SYNTHETIC
- LACTACYSTIN, STREPTOMYCES SP
- LACTACYSTIN (NATIVE)
- LACTACYSTIN
- (+)-LACTACYSTIN
- 3S-HYDROXY-2R-(1-HYDROXY-2-METHYLPROPYL)-4R-METHYL-5-OXO-2-PYRROLIDINECARBOXYLATE-N-ACETYL-L-CYSTEINE
- (2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBOXY-N-ACETYL-L-CYSTEINE THIOESTER