环芬尼
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- CAS号:
- 2624-43-3
- 英文名:
- Cyclofenil
- 英文别名:
- f6066;h3452;oginex;ondonid;sexovar;ici48213;fertodur;ondogyne;sexadieno;cyclofenyl
- 中文名:
- 环芬尼
- 中文别名:
- 双氯胍;环芬尼;双醋环烷;环己基亚甲基二苯酚二乙酸酯
- CBNumber:
- CB5212631
- 分子式:
- C23H24O4
- 分子量:
- 364.44
- MOL File:
- 2624-43-3.mol
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环芬尼化学性质
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熔点:
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135-136°
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沸点:
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415.62°C (rough estimate)
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密度:
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1.0986 (rough estimate)
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折射率:
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1.4433 (estimate)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 10 mg/mL at 60 °C, soluble
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形态:
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solid
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颜色:
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White to Off-White
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CAS 数据库:
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2624-43-3(CAS DataBase Reference)
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环芬尼性质、用途与生产工艺
Cyclofenil 是一种选择性雌激素受体 (estrogen receptor) 调节剂和排卵诱导剂。Cyclofenil 对 Vero 细胞中的登革热病毒复制具有抑制作用，EC50 为 1.62 μM。 Cyclofenil 具有抗登革热病毒的活性。
| Target | Value |
ERβ
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ERα
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Cyclofenil shows an inhibitory effect on dengue virus (DENV) replication in mammalian cells but not in mosquito cells.
Cyclofenil also inhibits the replication of Zika virus. A time-of-addition assay suggested that Cyclofenil may interfere with two stages of the Dengue virus (DENV) life cycle: the translation-RNA synthesis and assembly-maturation stages. The level of intracellular infectious particles decreased more drastically after treatment with Cyclofenil than the viral RNA level do, indicating that the assembly-maturation stage might be the main target of Cyclofenil.
The number of estrogen receptors α (ERα) and β (ERβ)-immunoreactive (-ir) cells is determined of each stage of the estrous cycle in intact rats. Additionally, the effects of blocking ERα and ERβ on ovulation rate on diestrus-2 or proestrus day through the microinjection of methyl-piperidino-pyrazole (MPP) or Cyclofenil in either side of preoptic-anterior hypothalamic area (POA-AHA) are evaluated. The number of ERα-ir and ERβ-ir cells in POA-AHA varied in each phase of estrous cycle. Either MPP or Cyclofenil in the right side of POA-AHA on diestrus-2 day reduced the ovulation rate, while at proestrus day it was decreased in rats treated in either side with MPP, and in those treated with Cyclofenil in the left side. MPP or Cyclofenil produced a decrease in the surge of luteinizing hormone levels (LH) and an increase in progesterone and follicle stimulating hormone (FSH).
环芬尼
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-W011100 | 环芬尼
Cyclofenil | 2624-43-3 | 50mg | 700元 |
| 2024/01/25 | HY-W011100 | 环芬尼
Cyclofenil | 2624-43-3 | 10mM * 1mLin DMSO | 770元 |
环芬尼
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环芬尼国内生产厂家
2624-43-3, 环芬尼 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
- 药靶配体
- 化工原料
- 合成
- 双氯胍
- 环己基亚甲基二苯酚二乙酸酯
- 双醋环烷
- 环芬尼
- 2624-43-3
- Cyclofenil,4,4'-(Cyclohexylidenemethylene)bisphenol1,1'-diacetate
- TIANFUCHEM--2624-43-3--High purity Cyclofenil factory price
- Cyclofenil USP/EP/BP
- Phenol, 4,4'-(cyclohexylidenemethylene)bis-, 1,1'-diacetate
- (Cyclohexylidenemethylene)
- (Cyclohexylidenemethylene)-bis(4,1-phenylene) diacetate
- Levosulpidire
- 4,4'-(Cyclohexylide
neMethylene)diphenol Diacetate Ester
- Cyclofenil,4,4′-Cyclohexylidenemethylenediphenol, 4-(Cyclohexylidenemethylene)-bis-phenol
- 4,4'-(Cyclohexylidenemethylene)bisphenol1,1'-diacetate
- acetic acid [4-[(4-acetoxyphenyl)-cyclohexylidene-methyl]phenyl] ester
- [4-[(4-acetyloxyphenyl)-cyclohexylidene-methyl]phenyl] ethanoate
- Bis(acetic acid) (cyclohexylidenemethylene)bis(4,1-phenylene)
- [4-[(4-Acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate
- (Cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate
- bis(p-Hydroxyphenyl)cyclohexyldienemethane diacetate
- bis(4-Acetoxyphenyl)-cyclohexylidenemethane
- 4-(Cyclohexylidenemethylene)-bis-phenol
- 4,4μ-Cyclohexylidenemethylenediphenol, 4-(Cyclohexylidenemethylene)-bis-phenol
- Cyclofenil,(Cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate
- CYCLODODECANONEOXIME
- 4-(CYCLOHEXYLIDENEMETHYLENE)-BIS-PHENOL DIACETATE
- 4,4'-CYCLOHEXYLIDENEMETHYLENEDIPHENOL DIACETATE
- CYCLOFENIL
- sexovar
- sexadieno
- ondonid
- ondogyne
- oginex
- ici48213
- h3452
- fertodur
- f6066
- cyclophenyl
- cyclophenil
- cyclofenyl
- bis-(p-hydroxyphenyl)-cyclohexylidenemethanediacetate
- bis-(p-acetoxyphenyl)-cyclohexylidenemethane
- alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-p-cresodiacetate
- 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-phenoacetate