BREVETOXIN PBTX-3
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- CAS号:
- 85079-48-7
- 英文名:
- BREVETOXIN PBTX-3
- 英文别名:
- PBTX-3;toxint-17;Gb 3 toxin;BREVETOXIN3;PUMILIOTOXIN;brevetoxint17;BREVETOXIN PBTX-3;DIHYDROBREVETOXIN B;BKMHDYJRAAJTAD-RXUQWMQDSA-N;42-Hydroxy-42-deoxobrevetoxin B
- 中文名:
- BREVETOXIN PBTX-3
- 中文别名:
- 短裸甲藻毒素3;化合物 T10609
- CBNumber:
- CB5221763
- 分子式:
- C50H72O14
- 分子量:
- 897.1
- MOL File:
- 85079-48-7.mol
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BREVETOXIN PBTX-3化学性质
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密度:
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1.190±0.06 g/cm3(Predicted)
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储存条件:
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-20C
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溶解度:
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DMSO: soluble,Ethanol: soluble,Methanol: soluble
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形态:
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Solid
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酸度系数(pKa):
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13.78±0.70(Predicted)
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BREVETOXIN PBTX-3性质、用途与生产工艺
Brevetoxin-3 (PbTx-3) 是一种有效的变构电压门控 Na+ 通道 (Na+ channels) 激活剂，具有多个活性中心 (A 环内酯，R 侧链的 C-42)。Brevetoxin-3 (PbTx-3) 对电压敏感的 Na+ 通道的位点 5 具有高亲和力，抑制 Na+ 通道的失活并延长这些通道的平均打开时间。Brevetoxin-3 (PbTx-3) 可导致气道高反应性 (AHR) 延长和肺部炎症。
IC50: voltage-gated Na
+
channel
Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV).
Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues.
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Animal Model:
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Pregnant CD-1 mice
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Dosage:
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2.8 μg/kg
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Administration:
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Intratracheal instillation; 2.8 μg/kg; gestational days 15–18
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Result:
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Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure.
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BREVETOXIN PBTX-3
上下游产品信息
上游原料
下游产品
85079-48-7, BREVETOXIN PBTX-3 相关搜索:
- 化合物 T10609
- 短裸甲藻毒素3
- 85079-48-7
- Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem
- BKMHDYJRAAJTAD-RXUQWMQDSA-N
- Gb 3 toxin
- 42-Hydroxy-42-deoxobrevetoxin B
- 42-Deoxo-42-hydroxybrevetoxin B
- BREVETOXIN3
- PBTX-3
- Brevetoxin B, 42-deoxo-42-hydroxy-
- toxint-17
- brevetoxint17
- PUMILIOTOXIN
- BREVETOXIN PBTX-3, PTYCHODISCUS BREVIS
- BREVETOXIN PBTX-3
- DIHYDROBREVETOXIN B