Kynurenic acid sodium salt
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- CAS号:
- 2439-02-3
- 英文名:
- Kynurenic acid sodium salt
- 英文别名:
- Kynurenic acid (sodium);Kynurenic acid sodium salt;4-Hydroxyquinoline-2-carboxylicacidsodiumsalt
- 中文名:
- Kynurenic acid sodium salt
- 中文别名:
- 犬尿喹啉酸钠盐;化合物 T22892;4-羟基喹啉-2-甲酸钠
- CBNumber:
- CB52487574
- 分子式:
- C10H6NNaO3
- 分子量:
- 230.19571
- MOL File:
- 2439-02-3.mol
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Kynurenic acid sodium salt化学性质
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储存条件:
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Store at RT
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溶解度:
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DMSO : 50 mg/mL (235.67 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
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形态:
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Powder
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颜色:
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Pale
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Kynurenic acid sodium salt性质、用途与生产工艺
Kynurenic acid sodium 是一种内源性色氨酸代谢物,是针对靶点 NMDA, glutamate, α7 nicotinic acetylcholine receptor 的光谱性拮抗剂。Kynurenic acid sodium 也是 GPR35/CXCR8 的激动剂。
Target: GPR35, NMDA, glutamate, glutamate, α7 nicotinic acetylcholine
GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G
qi/o
chimeric G proteins. Kynurenic acid stimulates [
35
S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC
50
in the low micromolar range.
Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals.
Kynurenic acid sodium salt
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-107512 | Kynurenic acid sodium salt Kynurenic acid sodium | 2439-02-3 | 100mg | 500元 |
2024/01/25 | HY-107512 | Kynurenic acid sodium salt Kynurenic acid sodium | 2439-02-3 | 10mM * 1mLin DMSO | 550元 |
Kynurenic acid sodium salt
生产厂家
2439-02-3, Kynurenic acid sodium salt 相关搜索:
- Glutamate
- 药靶配体
- C10H6NNaO3
- 犬尿喹啉酸钠盐
- 4-羟基喹啉-2-甲酸钠
- 化合物 T22892
- 2439-02-3
- Kynurenic acid (sodium)
- 4-Hydroxyquinoline-2-carboxylicacidsodiumsalt
- Kynurenic acid sodium salt