TCS PIM-1 1
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- CAS号:
- 491871-58-0
- 英文名:
- 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
- 英文别名:
- CS-1482;TCS PIM-1;SC 204330;TCS PIM-1 1;TCS PIM-1 1, >=98%;TCS PIM-1 1(sc-204330);SC 204330; TCS PIM 1-1;3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone;6-(5-Bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-
- 中文名:
- TCS PIM-1 1
- 中文别名:
- 化合物TCS PIM-1 1;PIM-1激酶抑制剂(TCS PIM-1 1);TCS PIM-1 1,ATP竞争性PIM-1激酶抑制剂;3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮;6-(5-溴-2-羟基苯)-2-氧代-4-苯基-1,2-二氢吡啶-3-腈
- CBNumber:
- CB52518751
- 分子式:
- C18H11BrN2O2
- 分子量:
- 367.2
- MOL File:
- 491871-58-0.mol
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TCS PIM-1 1化学性质
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沸点:
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592.6±50.0 °C(Predicted)
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密度:
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1.63±0.1 g/cm3(Predicted)
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储存条件:
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Store at +4°C
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溶解度:
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insoluble in H2O; insoluble in EtOH; ≥12.8 mg/mL in DMSO
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形态:
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solid
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酸度系数(pKa):
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6.93±0.10(Predicted)
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TCS PIM-1 1性质、用途与生产工艺
TCS PIM-1 1 (SC 204330)是一种有效的、选择性的 ATP-competitive Pim-1 kianse 抑制剂,其IC50值为50 nM,对 Pim-2 和 MEK1/MEK2 具有良好的选择性(IC50> 20000 nM)。
Target | Value |
Pim1
(Cell-free assay)
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50 nM
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TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein.
TCS PIM-1 1
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上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-18086 | TCS PIM-1 1 | | 5 mg | 627元 |
2024/01/25 | HY-18086 | TCS PIM-1 1 TCS PIM-1 1 | 491871-58-0 | 10mg | 1004元 |
491871-58-0, TCS PIM-1 1 相关搜索:
- Inhibitors
- 药靶配体
- 细胞生物学试剂
- 抑制剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- TCS PIM-1 1,ATP竞争性PIM-1激酶抑制剂
- 化合物TCS PIM-1 1
- 6-(5-溴-2-羟基苯)-2-氧代-4-苯基-1,2-二氢吡啶-3-腈
- PIM-1激酶抑制剂(TCS PIM-1 1)
- 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮
- 491871-58-0
- TCS PIM-1 1,scaffold,Pim,TCS PIM 1 1,Pim-1,pyridone,Inhibitor,Pim kinases,ATP-competitive,SC204330,SC-204330,inhibit,TCS PIM1 1
- 3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-
- TCS PIM-1 1(sc-204330)
- CS-1482
- SC 204330; TCS PIM 1-1
- TCS PIM-1 1, >=98%
- TCS PIM-1
- 6-(5-Bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile
- SC 204330
- TCS PIM-1 1
- 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone