奈斯布维
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- CAS号:
- 691852-58-1
- 英文名:
- Nesbuvir
- 英文别名:
- HCV 796;CS-1844;Nesbuvir;VB-19796);HCV-796 (Nesbuvir);nesbuvir = HCV-796;5-Cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-3-benzofurancarboxamide;3-Benzofurancarboxamide, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-;5-Cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-3-benzofurancarboxamide Nesbuvir HCV 796
- 中文名:
- 奈斯布维
- 中文别名:
- 奈斯布维;化合物NESBUVIR;5-环丙基-2-(4-氟苯基)-6-[(2-羟基乙基)(甲基磺酰基)氨基]-N-甲基-3-苯并呋喃甲酰胺
- CBNumber:
- CB52614363
- 分子式:
- C22H23FN2O5S
- 分子量:
- 446.49
- MOL File:
- 691852-58-1.mol
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奈斯布维化学性质
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密度:
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1.407
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储存条件:
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Store at -20°C
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溶解度:
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≥22.3 mg/mL in DMSO; insoluble in H2O; ≥97.8 mg/mL in EtOH with gentle warming
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形态:
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solid
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酸度系数(pKa):
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13.88±0.46(Predicted)
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奈斯布维性质、用途与生产工艺
Nesbuvir 是一种非核苷抑制剂，抑制丙型肝炎病毒(HCV) 非结构蛋白 5B (NS5B) 聚合酶。
EC50: 9 nM (NS3
V170A
), 13 nM (NS3
V170A
), 15 nM (NS3
K583T
), 13 nM (NS5B
I424V
)
Replicon cells are treated with 1 mg/mL G418 and combinations of the two compounds. Nesbuvir (HCV-796) is added to 40 or 80 nM (approximately 10 and 20 times the EC
50
in a 3-day replicon inhibition assay, respectively) and Boceprevir is added to 400 or 800 nM (approximately 2 and 4 times the EC
50
, respectively). The EC
50
s for Nesbuvir and Boceprevir for the parental replicon in the transient expression assay are comparable to those obtained in the 3-day inhibition assay with the stable replicon cells; the EC
50
for Nesbuvir in the transient expression assay is 14 nM, whereas it is 5 nM for the stable replicon; and the EC
50
for Boceprevir in the transient expression assay is 608 nM, whereas it is 201 nM for the stable replicon.
Among a huge variety of yet characterized nucleoside and non-nucleoside inhibitors (NNI), the benzofurane derivative NNI Nesbuvir (HCV-796) is demonstrated to yield significant antiviral effects in mice with chimeric human livers and in patients infected with HCV. HCV-796 binds to a hydrophobic binding pocket at the “palm” domain of NS5B; however, its mode of inhibition remains to be defined.
奈斯布维
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14775 | 5-环丙基-2-(4-氟苯基)-6-[(2-羟基乙基)(甲基磺酰基)氨基]-N-甲基-3-苯并呋喃甲酰胺
Nesbuvir | 691852-58-1 | 5mg | 2753元 |
| 2024/01/25 | HY-14775 | 5-环丙基-2-(4-氟苯基)-6-[(2-羟基乙基)(甲基磺酰基)氨基]-N-甲基-3-苯并呋喃甲酰胺
Nesbuvir | 691852-58-1 | 10mM * 1mLin DMSO | 3028元 |
691852-58-1, 奈斯布维 相关搜索:
- C22H23FN2O5S
- 化合物NESBUVIR
- 奈斯布维
- 5-环丙基-2-(4-氟苯基)-6-[(2-羟基乙基)(甲基磺酰基)氨基]-N-甲基-3-苯并呋喃甲酰胺
- 691852-58-1
- 3-Benzofurancarboxamide, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-
- CS-1844
- VB-19796)
- Nesbuvir
- HCV 796
- 5-Cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-3-benzofurancarboxamide Nesbuvir HCV 796
- HCV-796 (Nesbuvir)
- nesbuvir = HCV-796
- 5-Cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-3-benzofurancarboxamide