N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
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- CAS号:
- 420831-40-9
- 英文名:
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- 英文别名:
- AK-7;CS-922;AK 7, >=98%;AK-7;AK7;AK 7;SIRT2 Inhibitor II;SIRT2 Inhibitor,AK-7;SIRT2 Inhibitor II, AK-7;SIRT2 INHIBITOR II;AK7;AK 7;3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide;N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
- 中文名:
- N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
- 中文别名:
- 化合物AK-1;AK-7,中枢活性SIRT2抑制剂;3-(氮杂环庚烷-1-基磺酰基)-N-(3-溴苯基)苯甲酰胺;N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
- CBNumber:
- CB52639218
- 分子式:
- C19H21BrN2O3S
- 分子量:
- 437.35
- MOL File:
- 420831-40-9.mol
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N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺化学性质
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密度:
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1.469±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: ≥15mg/mL
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形态:
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powder
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酸度系数(pKa):
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12.28±0.70(Predicted)
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颜色:
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white to tan
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺性质、用途与生产工艺
AK-7 是一种可透过细胞及血脑屏障的 SIRT2 抑制剂,IC50 值为 15.5 μM。
AK-7 (10 μM) reduces cholesterol levels in naive N2a neuroblastoma cells and hippocampal slice cultures from wild-type mice. AK-7 (1 μM) shows neuroprotective effect of AK-7 in striatal Huntington’s disease (HD) neurons. AK-7 (12.5 μM) decreases ratio of DA neurons in primary midbrain cultures.
AK-7 (15 mg/kg/dose, i.p.) is brain-permeable in wild-type and HD mice. AK-7 (10, 20 mg/kg, i.p.) improves the behavior and neuropathological phenotype and extends survival of R6/2 HD mice. AK-7 (20 mg/kg) ameliorates HD neuropathology in R6/2 mice. AK-7 also reduces the polyglutamine aggregation in R6/2 brain. In addition, AK-7 treated 140CAG mice show motor performance changes that parallel untreated wild-type mice, with the 20 mg/kg dose being most effective and significantly different from untreated 140CAG mice.
N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-16691 | AK-7 | | 5 mg | 687元 |
2024/01/25 | HY-16691 | N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺 AK-7 | 420831-40-9 | 10mg | 1100元 |
N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
生产厂家
420831-40-9, N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺 相关搜索:
- 药靶配体
- AK-7,中枢活性SIRT2抑制剂
- 3-(氮杂环庚烷-1-基磺酰基)-N-(3-溴苯基)苯甲酰胺
- 化合物AK-1
- N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
- 420831-40-9
- SIRT2 Inhibitor II
- SIRT2 INHIBITOR II;AK7;AK 7
- CS-922
- SIRT2 Inhibitor II, AK-7
- AK-7;AK7;AK 7
- Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-
- AK-7
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- AK 7, >=98%
- N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide SIRT2 Inhibitor,AK-7
- SIRT2 Inhibitor,AK-7
- N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide