1015073-42-3
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- CAS号:
- 1015073-42-3
- 英文名:
- PSI7409
- 英文别名:
- PSI7409;PSI-7409;PSI 7409;Remdesivir Impurity 51;sofosbuvir 5‘ - triphosphate;Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-;(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
- 中文名:
- 1015073-42-3
- 中文别名:
- 瑞德西韦杂质51;化合物 T12572
- CBNumber:
- CB52666746
- 分子式:
- C10H16FN2O14P3
- 分子量:
- 500.16
- MOL File:
- 1015073-42-3.mol
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1015073-42-3化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic
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1015073-42-3性质、用途与生产工艺
PSI-7409是 Sofosbuvir (PSI-7977) 的5'-三磷酸活性代谢物。Sofosbuvir (PSI-7977) 是选择性和高活性的 HCV 核苷酸类似物抑制剂。
PSI-7409 inhibits the enzymatic activities of these NS5BΔ21 polymerases in a dose-dependent manner. The IC
50
s for PSI-7409 against GT 1b, 2a, 3a, and 4a NS5B polymerases are 1.6 μM, 2.8 μM, 0.7 μM, and 2.6 μM, respectively. PSI-7409 is a weak inhibitor of DNA Pol α (IC
50
=550 μM). DNA Pol β and γ are not inhibited by 1 mM PSI-7409. A significant amount of RNA product is made in the presence of 500 μM PSI-7409, about 85%. In clone A cells, the levels of PSI-7409 gradually increases to a maximum concentration of about 25 μm over a period of 48 h. PSI-7409 forms at a much faster rate in primary human hepatocytes, achieving a maximum intracellular concentration of ∼100 μM at 4 h and remains at that concentration for 48 h.
1015073-42-3
上下游产品信息
上游原料
1-((2R,3S,4R,5R)-3,4-二羟基-5-(羟甲基)-3-甲基四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮
3',5'-O-(四异丙基二硅氧烷-1,3-二基)-2'-氧代尿苷
索非布韦杂质25
(2'R)-2'-脱氧-2'-氟-2'-甲基脲苷
3',5'-O-(1,1,3,3-四异丙基-1,3-二硅氧烷)尿苷
尿苷
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2023/03/20 | HY-15745 | 1015073-42-3
PSI-7409 | 1015073-42-3 | 1mg | 2600元 |
| 2023/03/20 | HY-15745 | 1015073-42-3
PSI-7409 | 1015073-42-3 | 5mg | 7800元 |
1015073-42-3, 1015073-42-3 相关搜索:
- C10H16FN2O14P3
- 瑞德西韦杂质51
- 化合物 T12572
- 1015073-42-3
- Remdesivir Impurity 51
- sofosbuvir 5‘ - triphosphate
- Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-
- (2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
- PSI-7409
- PSI7409
- PSI 7409