AZD2932
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- CAS号:
- 883986-34-3
- 英文名:
- AZD 2932
- 英文别名:
- CS-1792;AZD 2932;AGN-PC-00AQ5T;AZD 2932 USP/EP/BP;AZD 2932; AZD-2932; AGN-PC-00AQ5T;AZD2932;2-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide;Benzeneacetamide, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-;2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide AZD2932;Platelet-derived growth factor receptor,Inhibitor,VEGFR,c-Kit,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,Vascular endothelial growth factor receptor,FLT3,SCFR,AZD-2932,AZD2932,inhibit,PDGFR,AZD 2932,CD117,CD135
- 中文名:
- AZD2932
- 中文别名:
- 化合物AZD2932;多靶点激酶抑制剂(AZD2932)
- CBNumber:
- CB52667071
- 分子式:
- C24H25N5O4
- 分子量:
- 447.49
- MOL File:
- 883986-34-3.mol
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AZD2932化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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crystalline solid
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AZD2932性质、用途与生产工艺
AZD2932 是一种有效的多靶点蛋白酪氨酸激酶抑制剂，对VEGFR-2，PDGFRβ，Flt-3，和 c-Kit 的 IC50 分别为 8 nM，4 nM，7 nM，和 9 nM。
AZD2932 effectively inhibits the activities of VEGFR-2 (IC50, 8 nM), PDGFRβ (IC50,4 nM), Flt-3 (IC50, 7 nM), and c-Kit (IC50, 9 nM). AZD2932 inhibits both PDGFRα and PDGFRβ phosphorylation with a correlation close to 1:1. AZD2932 does not inhibit the various cytochrome P450 isoforms with the worst IC50 being against 2C9 (8.0 μM). AZD2932 has no activity against hERG (IC50, 137 μM).
In C6 rat glial tumor model, AZD2932 (p.o., b.i.d.) results in significant TGI of 64% for both 50 and 12.5 mg/kg doses. Growth of Calu-6 tumor is inhibited by 81% and 72% at 50 and 12.5 mg/kg b.i.d. (p.o.) and LoVo tumors by 67% at 50 mg/kg b.i.d (p.o.). AZD2932 (3–50 mg/kg, p.o.) causes 60–80% inhibition of both p-VEGFR-2 and p-PDGFRβ. Single bolus oral doses of AZD2932 results in dose-related inhibition of PDGFRa phosphorylation 6 h after dosing.
AZD2932
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-18179 | AZD2932
AZD2932 | 883986-34-3 | 5mg | 630元 |
| 2024/01/25 | HY-18179 | AZD2932
AZD2932 | 883986-34-3 | 10mM * 1mLin DMSO | 693元 |
883986-34-3, AZD2932 相关搜索:
- Inhibitors
- 药靶配体
- 标准品
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- C24H25N5O4
- 化合物AZD2932
- 多靶点激酶抑制剂(AZD2932)
- 883986-34-3
- Platelet-derived growth factor receptor,Inhibitor,VEGFR,c-Kit,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,Vascular endothelial growth factor receptor,FLT3,SCFR,AZD-2932,AZD2932,inhibit,PDGFR,AZD 2932,CD117,CD135
- Benzeneacetamide, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-
- CS-1792
- AGN-PC-00AQ5T
- AZD 2932; AZD-2932; AGN-PC-00AQ5T;AZD2932
- AZD 2932 USP/EP/BP
- 2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide AZD2932
- 2-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
- AZD 2932