氟替卡松
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- CAS号:
- 90566-53-3
- 英文名:
- Fluticasone
- 英文别名:
- futikasong;FLUTICASONE;Fluticasone USP/EP/BP;Fluticasone Dipropionate;FLUTICASONE CAS 90566-53-3;FluticasonePropionate98.5%;6α,9-Difluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid S-(fluoromethyl) ester;6α,9-Difluoro-16α-methyl-11β-hydroxy-17-hydroxy-3-oxoandrosta-1,4-diene-17β-carbothioic acid S-(fluoromethyl) ester;Androsta-1,4-diene-17- Carbothioic acid, 6,9-difluoro- 11,17-dihydroxy-16-Methyl-3- oxo-, S-(fluoroMethyl) ester, (6α,11β,16α,17α)-;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6.alpha.,11.beta.,16.alpha.,17.alpha.)-
- 中文名:
- 氟替卡松
- 中文别名:
- 氟替卡松;丙酸氟替卡松杂质R;舒利迭(氟替卡松)
- CBNumber:
- CB5274961
- 分子式:
- C22H27F3O4S
- 分子量:
- 444.51
- MOL File:
- 90566-53-3.mol
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氟替卡松化学性质
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熔点:
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237-239 °C
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沸点:
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553.2±50.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Acetonitrile (Slightly), Chloroform (Slightly)
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酸度系数(pKa):
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11.66±0.70(Predicted)
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形态:
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Solid
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic, Unstable in Solution
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CAS 数据库:
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90566-53-3(CAS DataBase Reference)
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氟替卡松性质、用途与生产工艺
氟替卡松为强效吸入型糖皮质激素,作用同布地奈德。适用于哮喘和哮喘性支气管炎。
本品是一种作用于局部的强效糖皮质激素,具有强效的抗炎活性。本品的绝对口服生物利用度极低(<1%)。推荐剂量经鼻腔吸入给药后,能迅速减轻哮喘症状。其血浆浓度很低,大多数患者未检测出其全身性活性,因而对下丘脑-垂体-肾上腺轴的抑制作用极小。然而,不同个体的差异很大,应采用能有效控制症状的最小剂量。
1. 不良反应罕见,长期大剂量使用可能导致全身性反应(参见氢化可的松)。
2. 气雾剂:①非常罕见口腔以及咽喉的念珠菌病。用药后,以清水漱口可能对病人有所帮助。有症状的念珠菌病可局部用抗真菌药物治疗,同时可以继续使用。②有些病人吸入本药会引起声嘶,用药后应用清水漱口。③非常罕见异常支气管痉挛,应立即用速效吸入型支气管扩张剂治疗,并立即停止使用本吸入气雾剂。
3. 鼻喷雾剂:使用后有令人不愉快的味道和气味,头痛,并可引起鼻、喉部干燥、刺激等。
1. 氟替卡松与酮康唑、利托那韦等强效CYP3A4酶抑制药合用,本药血药浓度、生物利用度及全身不良反应发生率增加。
2. 与安非拉酮合用,本药可降低癫痫发作阈值,不能合用。
氟替卡松
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90566-53-3, 氟替卡松 相关搜索:
氟替卡松丙酸酯中间体E 氟替卡松杂质 糠酸氟替卡松奥瑞特杂质C (7A,17B)-7-[9-[(4,4,5,5,5-五氟戊基)硫]壬基]雌甾-1,3,5(10)-三烯-3,17-二醇 布地奈德 氟替卡松丙酸酯 氟米松酸 6Α,9Α-二氟-11Β-羟基-16Α-甲基-3-氧代-17Α-(丙酰氧基)雄甾-1,4-二烯-17Β-羧酸 (6a,11b,16a)-6,9-二氟-11-羟基-16-甲基雄甾-1,4-二烯-3,17-二酮 氟及卡松丙酸酯 氟替卡松
- API
- 原料
- 杂质
- 原料药
- 激素调节类
- 医用原料
- 原料中间体-原料药
- 甾体激素原料中间体
- 医药原料
- 化学原药
- C22H27F3O4S
- 丙酸氟替卡松杂质R
- 氟替卡松
- 舒利迭(氟替卡松)
- 90566-53-3
- futikasong
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)-S-(fluoromethyl)6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioate
- FLUTICASONE CAS 90566-53-3
- Fluticasone USP/EP/BP
- S-(fluoromethyl) (6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioate
- Androsta-1,4-diene-17- Carbothioic acid, 6,9-difluoro- 11,17-dihydroxy-16-Methyl-3- oxo-, S-(fluoroMethyl) ester, (6α,11β,16α,17α)-
- Fluticasone Dipropionate
- 6α,9-Difluoro-16α-methyl-11β-hydroxy-17-hydroxy-3-oxoandrosta-1,4-diene-17β-carbothioic acid S-(fluoromethyl) ester
- 6α,9-Difluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid S-(fluoromethyl) ester
- Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6.alpha.,11.beta.,16.alpha.,17.alpha.)-
- FluticasonePropionate98.5%
- FLUTICASONE
- (6s,9s,10s,11s,13s,14s,16r,17r)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one