PURVALANOL A
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- CAS号:
- 212844-53-6
- 英文名:
- PURVALANOL A
- 英文别名:
- NG-60;PurvaL;CH61386;CS-1631;PURVALANOL A;CDKinhibitor;(R)-Purvalanol A;NG 60;NG60;NG-60;PURVALANOLA, >98%;PurvalanolA/CH61386
- 中文名:
- PURVALANOL A
- 中文别名:
- PURVALANOL A 抑制剂;CDK抑制剂(PURVALANOL A);(R)-2-((6-((3-氯苯基)氨基)-9-异丙基-9H-嘌呤-2-基)氨基)-3-甲基丁-1-醇
- CBNumber:
- CB5283664
- 分子式:
- C19H25ClN6O
- 分子量:
- 388.89
- MOL File:
- 212844-53-6.mol
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PURVALANOL A化学性质
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沸点:
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590.5±60.0 °C(Predicted)
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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methylene chloride: 50 mg/mL, clear, colorless
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形态:
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powder
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酸度系数(pKa):
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14.51±0.10(Predicted)
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颜色:
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off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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PURVALANOL A性质、用途与生产工艺
Purvalanol A 是一种有效的,细胞渗透性 CDK 抑制剂,对cdc2-cyclin B,cdk2-cyclin A,cdk2-cyclin E,和 cdk4-cyclin D1的 IC50 分别为 4 nM,70 nM,35 nM,和 850 nM。
Purvalanol A decreases cell viability in dose-dependent manner in MCF-7 and MDA-MB-231 cell lines. Purvalanol A induces cell viability loss by 50 % in MCF-7 cells but MDA-MB-231 cells sre less sensitive to Purvalanol A (32 % decreases in cell viability). Purvalanol A induces mitochondria-mediated apoptosis in MCF-7 and MDA-MB-231 cells. Purvalanol A effectively prevents c-Src-mediated transformation by inhibiting both cell cycle progression and c-Src signaling, and effectively suppresses the anchorage independent growth of some human cancer cells in which c-Src is up-regulated. Purvalanol A has a stronger inhibitory effect on the anchorage-independent growth of HT29 and SW480 human colon cancer cells.
Purvalanol A 是一种有效的,细胞渗透性 CDK 抑制剂,对cdc2-cyclin B,cdk2-cyclin A,cdk2-cyclin E,和 cdk4-cyclin D1的 IC50 分别为 4 nM,70 nM,35 nM,和 850 nM。Purvalanol A 可诱导内质网应激介导的凋亡与自噬。
Target | Value |
Cdc2/CyclinB
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4 nM
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CDK2/CyclinE
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35 nM
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CDK2/CyclinA
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70 nM
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CDK4/CyclinD1
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850 nM
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Purvalanol A剂量依赖性降低MCF-7和MDA-MB-231细胞系中细胞活性。Purvalanol A在MCF-7细胞中诱导50%的细胞活性损失,而MDA-MB-231细胞对Purvalanol A敏感性较低(细胞活性减少32 %)。Purvalanol A在MCF-7和MDA-MB-231细胞中诱导线粒体介导的细胞凋亡。 Purvalanol A通过抑制细胞周期进程和c-Src信号通路,有效防止c-Src介导转化,并有效抑制一些c-Src上调的人类癌细胞贴壁不依赖性生长。 Purvalanol A对HT29和SW480人结肠癌细胞的贴壁依赖性生长具有强烈的抑制作用。
PURVALANOL A
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-18299A | PURVALANOL A Purvalanol A | 212844-53-6 | 2mg | 650元 |
2024/01/25 | HY-18299A | PURVALANOL A Purvalanol A | 212844-53-6 | 10mM * 1mLin DMSO | 659元 |
212844-53-6, PURVALANOL A 相关搜索:
- Signalling
- Inhibitors
- 合成有机化合物配体
- 细胞生物学试剂
- 小分子抑制剂
- 抑制剂
- 小分子抑制剂,天然产物
- Apoptosis and Cell Cycle
- Cell Cycle
- Cell Cycle Regulators
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- C19H25ClN6O
- PURVALANOL A 抑制剂
- (R)-2-((6-((3-氯苯基)氨基)-9-异丙基-9H-嘌呤-2-基)氨基)-3-甲基丁-1-醇
- CDK抑制剂(PURVALANOL A)
- 212844-53-6
- (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
- PURVALANOL A USP/EP/BP
- 1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-
- PurvaL
- PURVALANOLA, >98%
- CS-1631
- NG 60;NG60;NG-60
- Purvalanol A - CAS 212844-53-6 - Calbiochem
- NG-60, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine
- (R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino)-3-methylbutan-1-ol
- (R)-Purvalanol A
- Purvalanol A(NG 60)
- PurvalanolA/CH61386
- CDKinhibitor
- PurvalanolA,CDKinhibitor
- 2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanolCDKinhibitor.
- CH61386
- 2-(1R-ISOPROPYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYL-PURINE
- 2-(1R-ISOPROPOYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
- (2R)-2-[[6-[(3-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
- 6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE
- NG-60
- PURVALANOL A