CS-2092
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- CAS号:
- 676128-63-5
- 英文名:
- RSV604
- 英文别名:
- RSV604;CS-2092;RSV604;RSV 604;Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)-;(S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea;virus,Respiratory syncytial virus,A 60444,respiratory,protein,inhibit,RSV,syncytial,A-60444,Inhibitor,A60444,RSV604,RSV 604,nucleocapsid,RSV-604
- 中文名:
- CS-2092
- 中文别名:
- 化合物RSV604
- CBNumber:
- CB53041458
- 分子式:
- C22H17FN4O2
- 分子量:
- 388.39
- MOL File:
- 676128-63-5.mol
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CS-2092化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:20): 0.04 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
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形态:
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A solid
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CS-2092性质、用途与生产工艺
RSV604 (A-60444)是一种新型苯二氮卓类药物，是 respiratory syncytial virus (RSV) 的抑制剂，其EC50值为0.86 μM。RSV604 具有潜在治疗RSV相关疾病的可能性。Phase 2。
| Target | Value |
RSV
(Cell-free assay)
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0.86 μM(EC50)
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RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC
50
s ranging from 0.5 to 0.9 μM in plaque reduction assay.
RSV604 (6 days) inhibits RSV-induced HEp-2 cell death, with an EC
50
of 0.86 μM.
RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC
50
of 1.7 μM.
RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.
CS-2092
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-12993 | CS-2092
RSV604 | 676128-63-5 | 5mg | 700元 |
| 2024/01/25 | HY-12993 | CS-2092
RSV604 | 676128-63-5 | 10mM * 1mLin DMSO | 770元 |
676128-63-5, CS-2092 相关搜索:
- 化合物RSV604
- 676128-63-5
- virus,Respiratory syncytial virus,A 60444,respiratory,protein,inhibit,RSV,syncytial,A-60444,Inhibitor,A60444,RSV604,RSV 604,nucleocapsid,RSV-604
- RSV604;RSV 604
- (S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea
- Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)-
- CS-2092
- RSV604