无中文名称
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- CAS号:
- 1158279-20-9
- 英文名:
- HLCL-61 (hydrochloride)
- 英文别名:
- CS-2798;HLCL-61.HCl;HLCL61;HLCL 61;HLCL-61 (hydrochloride);HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE;1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride;Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor
- 中文名:
- 无中文名称
- 中文别名:
- HLCL-61 盐酸盐;化合物HLCL-61 HYDROCHLORIDE;PRMT5抑制剂(HLCL-61 HYDROCHLORIDE);1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐
- CBNumber:
- CB53122928
- 分子式:
- C23H25ClN2O
- 分子量:
- 380.92
- MOL File:
- 1158279-20-9.mol
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无中文名称化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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≥20.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
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形态:
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crystalline solid
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无中文名称性质、用途与生产工艺
HLCL-61 hydrochloride 是首创的小分子蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂。
Protein arginine methyltransferase 5
HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC
50
s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.
HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h.
Cell Viability Assay
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Cell Line:
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MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients)
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Concentration:
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1, 5, 10, 25, 50, 100 μM
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Incubation Time:
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24, 48, 72 hours
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Result:
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Dose-dependent reduction in cell viability with IC
50
s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.
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无中文名称
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐
HLCL-61 hydrochloride | 1158279-20-9 | 5mg | 500元 |
| 2024/01/25 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐
HLCL-61 hydrochloride | 1158279-20-9 | 10mM * 1mLin DMSO | 550元 |
1158279-20-9, 无中文名称 相关搜索:
- API
- 药靶配体
- 抑制剂
- 细胞生物学试剂
- 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐
- 化合物HLCL-61 HYDROCHLORIDE
- HLCL-61 盐酸盐
- PRMT5抑制剂(HLCL-61 HYDROCHLORIDE)
- 1158279-20-9
- Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor
- 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
- HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE
- CS-2798
- HLCL61;HLCL 61
- HLCL-61.HCl
- HLCL-61 (hydrochloride)