866927-10-8
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- CAS号:
- 866927-10-8
- 英文名:
- IC87201
- 英文别名:
- IC87201;IC-87201
(IC87201;IC87201 >=98% (HPLC);2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol;Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-;2-(((1H-Benzo[d][1,2,3]triazol-6-yl)amino)methyl)-4,6-dichlorophenol;IC 87201,IC87201,IC-87201,inhibit,iGluR,Inhibitor,Ionotropic glutamate receptors
- 中文名:
- 866927-10-8
- 中文别名:
- 化合物IC87201;2-(((1H-苯并[D][1,2,3]三唑-6-基)氨基)甲基)-4,6-二氯苯酚
- CBNumber:
- CB53146614
- 分子式:
- C13H10Cl2N4O
- 分子量:
- 309.15
- MOL File:
- 866927-10-8.mol
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866927-10-8化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);97.04(Max Conc. mM)
DMSO:29.0(Max Conc. mg/mL);93.81(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.81(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.23(Max Conc. mM)-
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形态:
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A solid
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866927-10-8性质、用途与生产工艺
IC87201 是 PSD95-nNOS 相互作用的抑制剂，可抑制 nMDAR 诱导的一氧化氮和 cGMP 的形成。
IC87201 (500-1800 μM) does not inhibit any of the probe-PDZ interactions involving PDZ1, PDZ2, PDZ3 of PSD-95 or nNOS-PDZ, or bind the canonical PDZ ligand binding sites. IC87201 binds to the β-finger of nNOS-PDZ and allosterically inhibits the nNOS-PDZ/PSD-95-PDZ interactions. IC87201 shows high degree of fluorescence-based artefactual signal when using TAMRA-nNOS as probe. IC87201 (20 μM) suppresses NMDA-stimulated cGMP formation relative to vehicle, in cultured hippocampal neurons. IC87201 (10 and 100 nM) attenuats NMDA/glycine-induced decreases in neurite outgrowth. IC87201 dose-dependently reduces NMDA-induced cGMP production in primary hippocampal neurons (DIV 14-21) with an IC
50
of 2.7 μM. IC87201 increases the number of branches at 10-30 μM when compared to control-treated neurons.
IC87201 (1, 4 and 10 mg/kg, i.p.) does not produce impairment in either spatial working memory or source memory. IC87201 (1 mg/kg) is effective in treating NMDA-induced thermal hyperalgesia in mice, with a corresponding peak plasma level of 55 ng/mL (or 0.2 μM).
866927-10-8
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100457 | IC87201 | | 5 mg | 812元 |
| 2024/01/25 | HY-100457 | 866927-10-8
IC87201 | 866927-10-8 | 10mg | 1300元 |
866927-10-8, 866927-10-8 相关搜索:
- API
- 2-(((1H-苯并[D][1,2,3]三唑-6-基)氨基)甲基)-4,6-二氯苯酚
- 化合物IC87201
- 866927-10-8
- IC 87201,IC87201,IC-87201,inhibit,iGluR,Inhibitor,Ionotropic glutamate receptors
- 2-(((1H-Benzo[d][1,2,3]triazol-6-yl)amino)methyl)-4,6-dichlorophenol
- 2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol
- IC-87201
(IC87201
- Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-
- IC87201 >=98% (HPLC)
- IC87201