VPS34
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- CAS号:
- 1383716-46-8
- 英文名:
- Vps
- 英文别名:
- Compound 19;Vps;PIK-III analogue;VPS34 inhibitor 1;Compound 19, PIK-III analogue;VPS34 inhibitor 1 (Compound 19);VPS34 inhibitor 1 (PIK-III analogue);VPS34 inhibitor 1 (Compound 19, PIK-III analogue);2-Propanol, 1-[[4'-(cyclopropylmethyl)-2-(4-pyridinylamino)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-;1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol
- 中文名:
- VPS34
- 中文别名:
- 化合物VPS34;VPS34INHIBITOR;1-((4'-(环丙基甲基)-2-(吡啶-4-基氨基)-[4,5'-联嘧啶]-2'-基)氨基)-2-甲基丙-2-醇;1-((4'-(环丙基甲基)-2-(吡啶-4-基氨基)-[4,5'-联吡啶]-2'-基)氨基)-2-甲基丙-2-醇
- CBNumber:
- CB53158772
- 分子式:
- C21H25N7O
- 分子量:
- 391.47
- MOL File:
- 1383716-46-8.mol
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VPS34化学性质
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沸点:
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676.1±65.0 °C(Predicted)
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密度:
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1.324±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 78 mg/mL (199.25 mM);Ethanol: Insoluble
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酸度系数(pKa):
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14.68±0.29(Predicted)
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水溶解性:
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Water: Insoluble
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VPS34性质、用途与生产工艺
VPS34 inhibitor 1 (Compound 19, PIK-III analogue)是有效的、选择性的VPS34抑制剂，IC50为15 nM。
| Target | Value |
VPS34
(Cell-free assay)
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15 nM
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Compound 19在脂质和蛋白激酶中非常具有选择性。compound 19能够阻止自噬底物p62, NCOA4, NBR1, NDP52和FTH1的降解。对细胞处理以compound 19能够增加脂化和非脂化形式的LC3。
在C57BL/6小鼠中检测compound 19的药代动力学类型。小鼠口服10 mg/kg Compound 19后，化合物能在其体内被快速吸收，具有中等水平的系统清除率（30 mL/min/kg，约为33%的肝血流量）、口服生物利用度良好(F% = 47)。基于这些药代动力学参数指标和细胞活性，compound 19是适于体内研究的候选化合物。小鼠口服50 mg/kg Compound 19，每两天一次，处理7天，将导致LC3-II积累、自噬能力呈时间依赖性减少趋势。在体内，Compound 19可抑制自噬反应。
VPS34
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | S8456 | VPS34
VPS34 inhibitor 1 (Compound 19) | 1383716-46-8 | 2mg | 1204.53元 |
| 2024/01/16 | S8456 | VPS34
VPS34 inhibitor 1 (Compound 19) | 1383716-46-8 | 5mg | 2212.23元 |
1383716-46-8, VPS34 相关搜索:
- 1-((4'-(环丙基甲基)-2-(吡啶-4-基氨基)-[4,5'-联嘧啶]-2'-基)氨基)-2-甲基丙-2-醇
- 化合物VPS34
- VPS34INHIBITOR
- 1-((4'-(环丙基甲基)-2-(吡啶-4-基氨基)-[4,5'-联吡啶]-2'-基)氨基)-2-甲基丙-2-醇
- 1383716-46-8
- VPS34 inhibitor 1 (Compound 19)
- inhibit,VPS34,oral,VPS-34 inhibitor 1 (Compound 19, PIK-III analogue),Inhibitor,VPS34 inhibitor 1 (Compound 19, PIK III analogue),lysosomal,degradation,Phosphoinositide 3-kinase,PI3K,selective,VPS34 inhibitor 1 (Compound 19, PIKIII analogue),Autophagy
- Compound 19
- 1-?[[4'-?(Cyclopropylmethyl)?-?2-?(4-?pyridinylamino)?[4,?5'-?bipyrimidin]?-?2'-?yl]?amino]?-?2-?methyl-2-?propanol
- 2-Propanol, 1-[[4'-(cyclopropylmethyl)-2-(4-pyridinylamino)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-
- VPS34 inhibitor 1 (PIK-III analogue)
- PIK-III analogue
- Compound 19, PIK-III analogue
- VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
- VPS34 inhibitor 1
- 1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol
- Vps