ML334
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- CAS号:
- 1432500-66-7
- 英文名:
- ML334
- 英文别名:
- ML334;LH601A;ML334,ML-334;(1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid;(1S,2R)-2-[(1S)-1-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-carbonyl]cyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 2-[[(1S)-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]-, (1S,2R)-
- 中文名:
- ML334
- 中文别名:
- 化合物 T12078
- CBNumber:
- CB53159380
- 分子式:
- C26H26N2O5
- 分子量:
- 446.49
- MOL File:
- 1432500-66-7.mol
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ML334化学性质
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沸点:
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693.1±55.0 °C(Predicted)
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密度:
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1.354±0.06 g/cm3(Predicted)
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储存条件:
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Store at 4°C, stored under nitrogen
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溶解度:
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DMSO: 40 mg/ml
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形态:
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A solid
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酸度系数(pKa):
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4.69±0.44(Predicted)
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ML334性质、用途与生产工艺
ML334 (LH601A) 是一种有效的，细胞可渗透的 NRF2 激活剂，通过抑制 Keap1-NRF2 蛋白质相互作用来发挥作用。ML334 以 Kd 值为 1μM 来结合 Keap1 Kelch 域。ML334 刺激 NRF2 表达和核易位并诱导抗氧化反应元件 (ARE) 活性。
ML334 (LH601A; 50-100 µM; 6-16 hours; HEK293 cells) treatment increases NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. And also enhances HO-1 mRNA expression between 4- and 7-fold at 6 h, with lesser fold-changes at 16 h.
ML334 (LH601A; 50-100 µM; 16 hours; HEK293 cells) treatment induces HO-1 and TRX1 proteins in HEK293 cells.
ML334 (LH601A) stimulates NRF2 expression and nuclear translocation in HEK293 cells.
RT-PCR
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Cell Line:
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HEK293 cells
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Concentration:
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50 μM or 100 µM
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Incubation Time:
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6 hours, 16 hours
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Result:
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Increased NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. Enhanced HO-1 mRNA expression between 4- and 7-fold at 6 h.
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Western Blot Analysis
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Cell Line:
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HEK293 cells
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Concentration:
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50 μM or 100 µM
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Incubation Time:
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16 hours
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Result:
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Enhanced HO-1 and TRX1 protein expression at 16 h.
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ML334
上下游产品信息
上游原料
下游产品
1432500-66-7, ML334 相关搜索:
- 化合物 T12078
- 1432500-66-7
- ML334,ML-334
- Cyclohexanecarboxylic acid, 2-[[(1S)-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]-, (1S,2R)-
- LH601A
- (1S,2R)-2-[(1S)-1-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-carbonyl]cyclohexane-1-carboxylic acid
- (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid
- ML334