867164-40-7
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- CAS号:
- 867164-40-7
- 英文名:
- TRC051384
- 英文别名:
- TRC051384;TRC 051384; TRC-051384;HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit;1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea;N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea;Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-
- 中文名:
- 867164-40-7
- 中文别名:
- TRC051384游离态;化合物TRC 051384;TRC 051384,热休克蛋白HSP70的诱导物;1-(2-吗啉乙基)-3-(4-(3-(6-吗啉吡啶-2-基)丙烯酰基)苯基)脲
- CBNumber:
- CB53171704
- 分子式:
- C25H31N5O4
- 分子量:
- 465.54
- MOL File:
- 867164-40-7.mol
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867164-40-7化学性质
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沸点:
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685.7±55.0 °C(Predicted)
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密度:
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1.260±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in EtOH; insoluble in H2O; ≥109 mg/mL in DMSO
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形态:
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solid
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酸度系数(pKa):
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13.47±0.46(Predicted)
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颜色:
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Yellow
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867164-40-7性质、用途与生产工艺
TRC051384是热休克蛋白70 (HSP70) 诱导剂。
TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line.
Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.
867164-40-7
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101712 | TRC051384 | | 1 mg | 400元 |
| 2024/04/30 | HY-101712 | 867164-40-7
TRC051384 | 867164-40-7 | 5mg | 900元 |
867164-40-7, 867164-40-7 相关搜索:
- API
- 药靶配体
- TRC 051384,热休克蛋白HSP70的诱导物
- 1-(2-吗啉乙基)-3-(4-(3-(6-吗啉吡啶-2-基)丙烯酰基)苯基)脲
- 化合物TRC 051384
- TRC051384游离态
- 867164-40-7
- HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit
- 1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea
- Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-
- N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea
- TRC 051384; TRC-051384
- TRC051384