886992-99-0
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- CAS号:
- 886992-99-0
- 英文名:
- Ac-Gly-BoroPro
- 英文别名:
- Ac-Gly-BoroPro;Ac-Gly-BoroPro?, >98%;AcGlyBoroPro,Ac Gly BoroPro;Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-
- 中文名:
- 886992-99-0
- 中文别名:
- 化合物 T10227;FAP抑制剂(AC-GLY-BOROPRO)
- CBNumber:
- CB53339599
- 分子式:
- C8H15BN2O4
- 分子量:
- 214.03
- MOL File:
- 886992-99-0.mol
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886992-99-0化学性质
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密度:
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1.26±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C,unstable in solution, ready to use.
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溶解度:
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DMSO : ≥ 50 mg/mL (233.61 mM)
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酸度系数(pKa):
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9.72±0.20(Predicted)
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886992-99-0性质、用途与生产工艺
Ac-Gly-BoroPro是选择性的 FAP 抑制剂,Ki 值为23 nM。
FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K
i
=23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (K
i
=377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with K
i
values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, making it less nucleophilic and therefore unlikely to cyclize.
886992-99-0
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上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-101801 | 886992-99-0 Ac-Gly-BoroPro | 886992-99-0 | 1mg | 2115元 |
2024/01/25 | HY-101801 | 886992-99-0 Ac-Gly-BoroPro | 886992-99-0 | 5mg | 8100元 |
886992-99-0, 886992-99-0 相关搜索:
- 细胞生物学试剂
- 化合物 T10227
- FAP抑制剂(AC-GLY-BOROPRO)
- 886992-99-0
- AcGlyBoroPro,Ac Gly BoroPro
- Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-
- Ac-Gly-BoroPro?, >98%
- Ac-Gly-BoroPro