Phe-Met-Arg-Phe amide
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- CAS号:
- 159237-99-7
- 英文名:
- Phe-Met-Arg-Phe amide trifluoroacetate
- 英文别名:
- Phe-Met-Arg-Phe amide trifluoroacetate;PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98%;Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%
- 中文名:
- Phe-Met-Arg-Phe amide
- 中文别名:
- 心兴奋肽H-PHE-MET-ARG-PHE-NH2
- CBNumber:
- CB53356170
- 分子式:
- C31H43F3N8O6S
- 分子量:
- 712.79
- MOL File:
- 159237-99-7.mol
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Phe-Met-Arg-Phe amide化学性质
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储存条件:
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Store at -20°C
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水溶解性:
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Water : ≥ 50 mg/mL (60.47 mM)
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序列:
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H-Phe-Met-Arg-Phe-NH2
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Phe-Met-Arg-Phe amide性质、用途与生产工艺
Phe-Met-Arg-Phe amide trifluoroacetate 是一种神经肽,在肽能神经元中激活 K+ 电流,ED50 为 23 nM,这种作用具有剂量依赖性。
ED50: 23 nM (K
+
current)
In the molluscan central nervous system, Phe-Met-Arg-Phe amide (FMRFa) acts on K
+
channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe amide activates a novel K
+
current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM).
Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
Phe-Met-Arg-Phe amide
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-P0249A | 159237-99-7 Phe-Met-Arg-Phe amide trifluoroacetate | 159237-99-7 | 5mg | 950元 |
2024/01/25 | HY-P0249A | 159237-99-7 Phe-Met-Arg-Phe amide trifluoroacetate | 159237-99-7 | 10mg | 1550元 |
Phe-Met-Arg-Phe amide
生产厂家
159237-99-7, Phe-Met-Arg-Phe amide 相关搜索:
- 目录肽
- 多肽
- 目录多肽
- 心兴奋肽H-PHE-MET-ARG-PHE-NH2
- 159237-99-7
- PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98%
- Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%
- Phe-Met-Arg-Phe amide trifluoroacetate