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1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID
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- CAS号:
- 1268335-33-6
- 英文名:
- 1,3-dihydro-1-hydroxy-2,1-Benzoxaborole-7-propanoic acid
- 英文别名:
- AN3661;AN3661,AN-3661;1,3-dihydro-1-hydroxy-2,1-Benzoxaborole-7-propanoic acid;2,1-Benzoxaborole-7-propanoic acid, 1,3-dihydro-1-hydroxy-;3-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanoic acid;3-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanoic acid
- 中文名:
- 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID
- 中文别名:
- 3-(1-羟基-1,3-二氢苯并[C][1,2]氧杂硼戊环-7-基)丙酸
- CBNumber:
- CB53361118
- 分子式:
- C10H11BO4
- 分子量:
- 206
- MOL File:
- 1268335-33-6.mol
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1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID化学性质
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熔点:
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150-151 °C
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沸点:
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402.7±55.0 °C(Predicted)
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (1213.59 mM)
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酸度系数(pKa):
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4.52±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID性质、用途与生产工艺
AN3661，一种有效的抗疟疾先导化合物，靶向恶性疟原虫的切割和多腺苷酸特异性因子同源物亚基 3 (PfCPSF3)。AN3661 可抑制恶性疟原虫实验室适应的菌株(平均 IC50=32 nM)，Ugandan 野外分离株 (平均 IC50=64 nM) 和小鼠 P. berghei 和 P. falciparum 的感染。
AN3661 is active at nanomolar (IC
50
=20-56 nM) concentrations against
P. falciparum
laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is similarly active in ex vivo studies of fresh Ugandan field isolates (mean ex vivo IC
50
=64 nM). AN3661 shows minimal cytotoxicity against mammalian cell lines, with the CC
50
60.5 μM against Jurkat cells, and all other CC
50
values greater than the highest concentrations tested (25 μM or above).
AN3661 inhibits the stability of
P. falciparum
transcripts.
AN3661 (50-200 mg.kg; p.o.; daily for 4 days) inhibits murine
P. berghei
infections with ED
90
(4 days) 0.34 mg/kg.
AN3661 is administered orally for 4 days, beginning on the third day of infection, the ED
90
4 days after initiation of treatment is 0.57 mg/kg.
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Animal Model:
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P. berghei
-infected mice (malaria model)
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Dosage:
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50, 100, 200 mg/kg
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Administration:
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Orally; daily for 4 days
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Result:
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Rapidly controlled parasitemias, with an ED
90
of 0.34 mg/kg. Daily dosages of 50 mg/kg and 100 mg/kg extended survival, and mice treated with 200 mg/kg per day demonstrated long-term cures.
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1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-128204 | 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID
AN3661 | 1268335-33-6 | 5mg | 1600元 |
| 2024/08/19 | HY-128204 | 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID
AN3661 | 1268335-33-6 | 10mM * 1mLin DMSO | 1760元 |
1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID
生产厂家
1268335-33-6, 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID 相关搜索:
- 3-(1-羟基-1,3-二氢苯并[C][1,2]氧杂硼戊环-7-基)丙酸
- 1268335-33-6
- 2,1-Benzoxaborole-7-propanoic acid, 1,3-dihydro-1-hydroxy-
- AN3661,AN-3661
- AN3661
- 3-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanoic acid
- 3-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanoic acid
- 1,3-dihydro-1-hydroxy-2,1-Benzoxaborole-7-propanoic acid