宾达氮芥
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- CAS号:
- 16506-27-7
- 英文名:
- Bendamustine
- 英文别名:
- 4-(5-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid;Bendamustine;4-(5-(Bis(2-chloroethyl);-1-methyl-1H-benzo[d]imidazol-2-yl);5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid;5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid;4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;1H-BenziMidazole-2-butanoicacid, 5-[bis(2-chloroethyl)aMino]-1-Methyl-;alkylating,SDX-105,inhibit,DNA Alkylator/Crosslinker,antimetabolite,purine,anticancer,Apoptosis,Bendamustine,SDX 105,Inhibitor,DNA;BendamustineQ: What is
Bendamustine Q: What is the CAS Number of
Bendamustine Q: What is the storage condition of
Bendamustine Q: What are the applications of
Bendamustine
- 中文名:
- 宾达氮芥
- 中文别名:
- 宾达氮芥;苯达莫司汀;4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸;4-(5-(双(2-氯乙基)氨基)-1-甲基-1H-苯并[D]咪唑-2-基)丁酸;盐酸苯达莫司汀/4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸
- CBNumber:
- CB5340488
- 分子式:
- C16H21Cl2N3O2
- 分子量:
- 358.26
- MOL File:
- 16506-27-7.mol
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宾达氮芥化学性质
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沸点:
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585.2±50.0 °C(Predicted)
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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-20°C, protect from light
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溶解度:
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DMSO : 100 mg/mL (279.13 mM; Need ultrasonic)
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酸度系数(pKa):
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4.50±0.10(Predicted)
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宾达氮芥性质、用途与生产工艺
Bendamustine (SDX105)是一种氮芥药物，用于治疗慢性淋巴细胞白血病、多发性骨髓瘤和非霍奇金淋巴瘤。
DNA Alkylator/Crosslinker
Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.
Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC
25
s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.
Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.
宾达氮芥
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | S5939 | 宾达氮芥
Bendamustine | 16506-27-7 | 5mg | 959.1元 |
| 2024/01/16 | S5939 | Bendamustine (SDX105) | 16506-27-7 | 10mM (1mL in DMSO) | 1122.03元 |
宾达氮芥
生产厂家
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宾达氮芥国内生产厂家
16506-27-7, 宾达氮芥 相关搜索:
- WHO基本药物配体
- 化工
- 杂环类
- C15H19Cl2N3O2
- C16H21Cl2N3O2
- 4-(5-(双(2-氯乙基)氨基)-1-甲基-1H-苯并[D]咪唑-2-基)丁酸
- 盐酸苯达莫司汀/4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸
- 4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸
- 苯达莫司汀
- 宾达氮芥
- 16506-27-7
- alkylating,SDX-105,inhibit,DNA Alkylator/Crosslinker,antimetabolite,purine,anticancer,Apoptosis,Bendamustine,SDX 105,Inhibitor,DNA
- 4-(5-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid
- BendamustineQ: What is
Bendamustine Q: What is the CAS Number of
Bendamustine Q: What is the storage condition of
Bendamustine Q: What are the applications of
Bendamustine
- 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
- 1H-BenziMidazole-2-butanoicacid, 5-[bis(2-chloroethyl)aMino]-1-Methyl-
- 4-(5-(Bis(2-chloroethyl)
- -1-methyl-1H-benzo[d]imidazol-2-yl)
- Bendamustine
- 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid
- 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid