促甲状腺素释放激素游离酸
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- CAS号:
- 24769-58-2
- 英文名:
- TRH
- 英文别名:
- TRH;TRH-OH;PYR-HP;TRH acid;Acid-TRH;GLP-HIS-PRO;PYR-HIS-PRO;Deamido-TRH;PGLU-HIS-PRO;PYR-HIS-PRO-OH
- 中文名:
- 促甲状腺素释放激素游离酸
- 中文别名:
- 化合物T7407;普罗瑞林EP杂质D;促甲状腺素释放激素游离酸;促甲状腺素释放激素游离酸(普罗瑞林);促甲状腺激素释放激素TRH, FREEACID;ANTI-TRH ANTIBODY-促甲状腺素释放激素抗体
- CBNumber:
- CB5408946
- 分子式:
- C16H21N5O5
- 分子量:
- 363.37
- MOL File:
- 24769-58-2.mol
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促甲状腺素释放激素游离酸化学性质
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沸点:
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942.1±65.0 °C(Predicted)
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密度:
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1.461±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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酸度系数(pKa):
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3.29±0.20(Predicted)
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促甲状腺素释放激素游离酸性质、用途与生产工艺
促甲状腺素释放激素游离酸外观上呈白色或类白色冻干粉末。
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH)是促甲状腺激素释放激素一种生理代谢产物。
TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [
3
H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na
+
channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na
+
current amplitude is reduced by 20-50%.
促甲状腺素释放激素游离酸
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24769-58-2, 促甲状腺素释放激素游离酸 相关搜索:
- 标准品
- 多肽
- 生化试剂
- Releasing Factors
- Peptides
- BioChemical
- Biochemicals and Reagents
- Amino Acids and Peptides
- 促甲状腺激素释放激素TRH, FREEACID
- 普罗瑞林EP杂质D
- ANTI-TRH ANTIBODY-促甲状腺素释放激素抗体
- 化合物T7407
- 促甲状腺素释放激素游离酸(普罗瑞林)
- 促甲状腺素释放激素游离酸
- 24769-58-2
- Thyrotropin Releasing Hormone (TRH), Free Acid,inhibit,ThyrotropinReleasing Hormone (TRH), Free Acid,Inhibitor,Thyrotropin-Releasing Hormone (TRH)
- Protirelin EP Impurity D
- L-Proline, 5-oxo-L-prolyl-L-histidyl-
- L-Pyroglutamyl-L-histidyl-L-proline
- Deamino-thyrotropin releasing hormone
- Deamido-TRH
- Deamido-thyrotropin-releasing factor
- Deamidated TRH
- Acid-TRH
- Acid thyroliberin
- Protirelin (free acid)
- thyrotropin-releasing hormone, deamido-
- THYROTROPIN-RELEASING HORMONE (FREE ACID)
- TRH
- TRH (FREE ACID)
- TRH-OH
- PYR-HP
- PYR-HIS-PRO-OH
- PYR-HIS-PRO
- PGLU-HIS-PRO
- GLP-HIS-PRO
- TRH acid