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网站主页 >> CAS数据库列表 >> (N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE

(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE

生物活性 靶点 体外研究 体内研究 (N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE 试剂级价格
(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE, 169505-93-5, 结构式
(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE
CAS号:
169505-93-5
英文名:
(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE
英文别名:
RS-17053;RS17053HCl;RS 17053 HYDROCHLORIDE;RS 17053 hydrochloride (RS-17053);RS 17053 hydrochloride (Synonyms: RS-17053);Beta Receptor,Adrenergic Receptor,inhibit,RS 17053 hydrochloride,RS17053,RS 17053,Inhibitor;(N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine)hydrochloride;(N-(2-(2-Cyclopropylmethoxyphenoxy)ethyl)-5-chloro-(a,a)-dimethyl-(1H)-indole-3-ethanamine)hydrochloride;(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE
中文名:
(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE
中文别名:
化合物 T16798;化合物RS 17053 HYDROCHLORIDE
CBNumber:
CB5417674
分子式:
C24H30Cl2N2O2
分子量:
449.42
MOL File:
169505-93-5.mol

(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE化学性质

储存条件:
Store at RT
溶解度:
insoluble in ethanol; <22.47mg/ml in DMSO
形态:
solid
颜色:
White
安全信息

(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE性质、用途与生产工艺

生物活性

RS 17053 hydrochloride 是一种有效的 α1A 肾上腺素受体 (α1A adrenoceptor) 的选择性拮抗剂，其在细胞膜中测得的 pKi 值为 9.1，功能分析的 pA2 值为 9.8。

靶点

pKi: 9.1 (α1 A adrenoceptor in native cell membrane)
pA2: 9.8 (α1 A adrenoceptor).

体外研究

In several tissues from rat and cloned adrenoceptors, RS 17053 hydrochloride displays high affinity for the α1A-adrenoceptor (pK i and pA 2 estimates of 9.1-9.9) and a 30-100-fold selectivity over the α1 B and the α1 D-adrenoceptor subtypes (pK i and pA 2 estimates of 7.7-7.8). However, in isolated smooth muscle preparations from human LUT tissues, RS 17053 hydrochloride antagonizes responses to NE only at high concentrations. Estimates of affinity (pA 2 ) at α1-adrenoceptors mediating NE-induced contractions are 7.5 in prostatic periurethral longitudinal smooth muscle (compared with 8.6 for prazosin), 6.9 in anterior fibromuscular stroma (prazosin, 8.9), and 7.1 in bladder neck (prazosin, 8.5).

体内研究

RS 17053 hydrochloride has a rapid onset of action, and a duration of action exceeding 60 min. RS 17053 hydrochloride pretreatment significantly alteres food intake [F(4, 132) 5 6.28, p , 0.0001]. 10 mg/kg RS-17053 significantly suppresses food intake.

(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE 上下游产品信息

上游原料

下游产品

(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/04/30HY-101336(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE
RS 17053 hydrochloride		169505-93-55mg850元
2024/04/30HY-101336(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE
RS 17053 hydrochloride		169505-93-510mM * 1mLin DMSO935元

(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE 生产厂家

全球有 24家供应商   (N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE国内生产厂家
供应商联系电话电子邮件国家产品数优势度
武汉易泰科技有限公司上海分公司 821-50328103-801 18930552037 3bsc@sina.com 中国 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com 美国 8449 60
上海一飞生物科技有限公司 021-65675885 18964387627 info@efebio.com 中国 9709 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
上海源溪生物科技有限公司 021-58447131 13564518121 sales@dcchemicals.com 中国 9414 58
济南思考化学有限公司 0531-0000 thinklifescience@163.com 中国 19690 58
ChemeGen 中国 18818260767 sales@chemegen.com 中国 11289 58
上海弘渠生物医药科技有限公司 88888888888 hongquchem@qq.com 中国 5132 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29834 58
TargetMol中国（陶术生物） 4008200310 marketing@tsbiochem.com 中国 24131 58
LEAPCHEM CO., LTD. +86-852-30606658 market18@leapchem.com 中国 43348 58
杭州摩库生物医药科技有限公司 +86-057181025280; +8617767106207 sales@molcore.com 中国 49739 58
ApexBio技术 sales@apexbt.com 美国 6254 58
 

169505-93-5, (N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE 相关搜索:

乙撑双硬脂酰胺 去离子水 (2R,3S/2S,3R)-3-(6-氯-5-氟嘧啶-4-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇盐酸盐
  • C24H29N2O2ClHCl
  • 化合物RS 17053 HYDROCHLORIDE
  • 化合物 T16798
  • 169505-93-5
  • Beta Receptor,Adrenergic Receptor,inhibit,RS 17053 hydrochloride,RS17053,RS 17053,Inhibitor
  • RS-17053
  • RS 17053 hydrochloride (Synonyms: RS-17053)
  • RS 17053 hydrochloride (RS-17053)
  • (N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine)hydrochloride
  • RS17053HCl
  • (N-(2-(2-Cyclopropylmethoxyphenoxy)ethyl)-5-chloro-(a,a)-dimethyl-(1H)-indole-3-ethanamine)hydrochloride
  • RS 17053 HYDROCHLORIDE
  • (N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE
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